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J Am Soc Nephrol 10:1317-1323, 1999
© 1999 American Society of Nephrology

REGULAR ARTICLES

Influence of Donor Factors on Early Function of Graft Kidneys

DEEPIKA SURI and TIMOTHY W. MEYER

Departments of Medicine, Palo Alto Veterans Administration Health Care Service and Stanford University, Palo Alto, California.

Correspondence to Dr. Timothy Meyer, Departments of Medicine, Palo Alto VAHCS and Stanford University, Palo Alto VAHCS, 3801 Miranda Avenue, Palo Alto, CA 94304. Phone: 415-493-5000, ext. 63314; Fax: 415-852-3411; E-mail: meyer.timothy_w{at}palo-alto.va.gov

Abstract. Factors which influence graft function can be divided into donor factors that affect both kidneys from the same donor equally and postdonor factors that affect each kidney individually. This study assessed the influence of donor factors on graft function early after transplantation. Sixty-one donors who provided kidneys that were transplanted locally into two separate recipients were identified. Recipient creatinine clearance values were estimated from serum creatinine concentrations using a computer model. Pairwise ANOVA showed that donor factors accounted for 35 to 45% of the variation in recipient creatinine clearance from 2 d to 2 wk posttransplantation. Although donor factors had a large aggregate effect during this period, individual factors that influenced graft function could not be identified from analysis of donor medical records. At 6 mo after transplantation, the effect of donor factors on graft function was no longer discernible. These results show that the condition of the donor exerts an important influence on graft function early after transplantation. More detailed study is required to identify individual factors that contribute to this effect.






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