Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LAFAYETTE, R. A.
Right arrow Articles by MYERS, B. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LAFAYETTE, R. A.
Right arrow Articles by MYERS, B. D.
J Am Soc Nephrol 10:1561-1565, 1999
© 1999 American Society of Nephrology

REGULAR ARTICLES

The Dynamics of Glomerular Filtration after Caesarean Section

RICHARD A. LAFAYETTE*, TAHIRA MALIK*, MAURICE DRUZIN{dagger}, GERALDINE DERBY* and BRYAN D. MYERS*

* Department of Medicine, Stanford University Medical Center, Stanford University School of Medicine, Stanford, California.
{dagger} Department of Obstetrics, Stanford University Medical Center, Stanford University School of Medicine, Stanford, California.

Correspondence to Dr. Richard A. Lafayette, Division of Nephrology, Stanford University Medical Center, Stanford, CA 94305-5114. Phone: 650-723-6247; Fax: 650-723-7917; E-mail: czar{at}leland.stanford.edu

Abstract. The objective of this study was to determine whether the glomerular hyperfiltration of pregnancy is maintained even after Caesarean section and, if so, to define the responsible hemodynamics. The dynamics of glomerular filtration were evaluated in 12 healthy women who had just completed an uncomplicated pregnancy and were delivered by Caesarean section. Age-matched but non-gravid female volunteers (n = 22) served as control subjects. GFR in postpartum women was elevated above control values by 41%; 149 ± 10 versus 106 ± 3 ml/min per 1.73 m2, respectively (P < 0.001). In contrast, corresponding renal plasma flow was the same in the two groups, such that the postpartum filtration fraction was significantly elevated by 20%. Computation of glomerular intracapillary oncotic pressure ({pi}GC) from knowledge of plasma oncotic pressure and the filtration fraction revealed this quantity to be significantly reduced in postpartum women, 20.6 ± 1.7 versus 26.1 ± 2.0 mmHg in control subjects (P < 0.001). A theoretical analysis of glomerular ultrafiltration suggests that depression of {pi}GC, the force opposing the formation of filtrate, is predominantly or uniquely responsible for the observed postpartum hyperfiltration.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
M. A. Hladunewich, R. A. Lafayette, G. C. Derby, K. L. Blouch, J. W. Bialek, M. L. Druzin, W. M. Deen, and B. D. Myers
The dynamics of glomerular filtration in the puerperium
Am J Physiol Renal Physiol, March 1, 2004; 286(3): F496 - F503.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. E. C. Milne, M. D. Lindheimer, and J. M. Davison
Glomerular heteroporous membrane modeling in third trimester and postpartum before and during amino acid infusion
Am J Physiol Renal Physiol, January 1, 2002; 282(1): F170 - F175.
[Abstract] [Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673