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J Am Soc Nephrol 11:319-329, 2000
© 2000 American Society of Nephrology

Effect of Gender on the Progression of Nondiabetic Renal Disease

A Meta-Analysis

JOEL NEUGARTEN, ANJALI ACHARYA and SHARON R. SILBIGER

Renal Division, Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York.

Correspondence to Dr. Joel Neugarten, Renal Laboratory, Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467. Phone: 718-920-4991; Fax: 718-920-6658.

There is previously published evidence that male gender is associated with a more rapid rate of progression of nondiabetic chronic renal disease. However, some investigators have concluded that no such association exists. To help resolve this issue, a meta-analysis was performed using 68 studies that met defined criteria and contained a total of 11,345 patients to evaluate the effect of gender on the progression of nondiabetic chronic renal disease. The results indicate that men with chronic renal disease of various etiologies show a more rapid decline in renal function with time than do women.




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