Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BAK, M.
Right arrow Articles by FLYVBJERG, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BAK, M.
Right arrow Articles by FLYVBJERG, A.
J Am Soc Nephrol 11:1287-1292, 2000
© 2000 American Society of Nephrology

REGULAR ARTICLES

Renal Enlargement Precedes Renal Hyperfiltration in Early Experimental Diabetes in Rats

MARTIN BAK*,{dagger}, KLAUS THOMSEN{dagger}, THORA CHRISTIANSEN{ddagger} and ALLAN FLYVBJERG*

* Medical Research Laboratories, Institute of Experimental Clinical Research, Aarhus University Hospital, Denmark
{dagger} Institute for Basic Psychiatric Research, Aarhus University Hospital, Denmark
{ddagger} Magnetic Resonance Research Centre, Aarhus University Hospital, Denmark.

Correspondence to Dr. Martin Bak, Institute for Basic Psychiatric Research, Aarhus University Hospital, Skovagervej 2, DK-8240 Risskov, Denmark. Phone : +45 77 89 3512 ; Fax : +45 77 89 3549 ; E-mail : martinbak{at}dadlnet.dk

Abstract. The order of appearance between renal hypertrophy and hyperfunction in early experimental diabetes is still disputed. The reason for previous discrepant results is believed to be methodologic problems, as most previous studies of renal function have been performed in anesthetized animals. In the present study in nondiabetic and streptozotocin-diabetic animals, renal volume was measured by a noninvasive magnetic resonance imaging technique, while renal function parameters were measured in conscious, chronically catheterized animals. To avoid artifacts caused by the procedures associated with induction of streptozotocin-diabetes (fasting, brief anesthesia, and transient hypoglycemia) on renal growth and function, diabetic animals were injected with insulin to obtain euglycemia for 4 d before study start. At day 0, insulin administration was withdrawn and all animals developed hyperglycemia within 12 h. Renal volume and kidney function were measured on days 0, 1, 2, 3, 5, and 7. Renal enlargement was detectable at day 1 (20%) and reached an increase of 40% at day 7. No changes were seen in effective renal plasma flow or effective renal vascular resistance within the first 7 d after development of hyperglycemia. GFR tended to rise on day 5 and was increased by 16% at day 7. The absolute proximal reabsorption showed a pronounced rise (30%) at day 7, whereas no change was seen in the proximal tubular fluid output. It is concluded that renal enlargement precedes renal hyperfunction in the early phase after onset of experimental diabetes.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Z. Levine, M. Iacovitti, and S. J. Robertson
Modulation of single-nephron GFR in the db/db mouse model of type 2 diabetes mellitus. II. Effects of renal mass reduction
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1840 - R1846.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. M. Foutz, P. R. Grimm, and S. C. Sansom
Insulin increases the activity of mesangial BK channels through MAPK signaling
Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1465 - F1472.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Rippe, A. Rippe, O. Torffvit, and B. Rippe
Size and charge selectivity of the glomerular filter in early experimental diabetes in rats
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1533 - F1538.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
G. Zerbini, R. Bonfanti, F. Meschi, E. Bognetti, P. L. Paesano, L. Gianolli, M. Querques, A. Maestroni, G. Calori, A. Del Maschio, et al.
Persistent Renal Hypertrophy and Faster Decline of Glomerular Filtration Rate Precede the Development of Microalbuminuria in Type 1 Diabetes
Diabetes, September 1, 2006; 55(9): 2620 - 2625.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
M. Ikegami-Kawai, A. Suzuki, I. Karita, and T. Takahashi
Increased Hyaluronidase Activity in the Kidney of Streptozotocin-Induced Diabetic Rats
J. Biochem., December 1, 2003; 134(6): 875 - 880.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. H.S. Wilson, S. E. Eckenrode, Q.-Z. Li, Q.-G. Ruan, P. Yang, J.-D. Shi, A. Davoodi-Semiromi, R. A. McIndoe, B. P. Croker, and J.-X. She
Microarray Analysis of Gene Expression in the Kidneys of New- and Post-Onset Diabetic NOD Mice
Diabetes, August 1, 2003; 52(8): 2151 - 2159.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T.-J. Hsieh, S.-L. Zhang, J. G. Filep, S.-S. Tang, J. R. Ingelfinger, and J. S. D. Chan
High Glucose Stimulates Angiotensinogen Gene Expression via Reactive Oxygen Species Generation in Rat Kidney Proximal Tubular Cells
Endocrinology, August 1, 2002; 143(8): 2975 - 2985.
[Abstract] [Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673