2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by PONTOGLIO, M. Search for Related Content PubMed PubMed Citation Articles by PONTOGLIO, M.

Hepatocyte Nuclear Factor 1, a Transcription Factor at the Crossroads of Glucose Homeostasis

Oncogenic Virus Unit, CNRS URA 1644, Biotechnology Department, Pasteur Institute, Paris, France.

Correspondence to Dr. Marco Pontoglio, Unité des Virus Oncogènes, CNRS URA 1644, Département des Biotechnologies, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France. Phone: 33 1 456 88514; Fax: 33 1 406 13033; E-mail: marcop{at}pasteur.fr

Abstract. Hepatocyte nuclear factor 1 (HNF1) is a transcription factor involved in the regulation of a large set of hepatic genes, including albumin, -fibrinogen, and 1-antitrypsin. HNF1 is expressed in the liver, digestive tract, pancreas, and kidney. Mice lacking HNF1 exhibit hepatic, pancreatic, and renal dysfunctions. HNF1-deficient mice fail to express the hepatic phenylalanine hydroxylase gene, giving rise to hyperphenylalaninemia. Renal proximal tubular reabsorption of glucose, phosphate, arginine, and other metabolites is affected, producing severe renal glucosuria, phosphaturia, and amino aciduria. Homozygous mutant mice also exhibit a dramatic insulin secretion defect. This dysfunction resembles that exhibited by patients with maturity-onset diabetes mellitus of the young type 3, who carry mutations in the human HNF1 gene in the heterozygous state. These data show that HNF1 is a major regulator of glucose homeostasis, regulating the expression of genes that are expressed in the liver, kidney, and pancreas.

This article has been cited by other articles:

				R. Kekuda, P. Saha, and U. Sundaram Role of Sp1 and HNF1 transcription factors in SGLT1 regulation during chronic intestinal inflammation Am J Physiol Gastrointest Liver Physiol, June 1, 2008; 294(6): G1354 - G1361. [Abstract] [Full Text] [PDF]

				N. Jonckheere, A. Vincent, M. Perrais, M.-P. Ducourouble, A. K.-v. Male, J.-P. Aubert, P. Pigny, K. L. Carraway, J.-N. Freund, I. B. Renes, et al. The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells J. Biol. Chem., August 3, 2007; 282(31): 22638 - 22650. [Abstract] [Full Text] [PDF]

				B. Desvergne, L. Michalik, and W. Wahli Transcriptional Regulation of Metabolism Physiol Rev, April 1, 2006; 86(2): 465 - 514. [Abstract] [Full Text] [PDF]

				T. Hiesberger, X. Shao, E. Gourley, A. Reimann, M. Pontoglio, and P. Igarashi Role of the Hepatocyte Nuclear Factor-1{beta} (HNF-1{beta}) C-terminal Domain in Pkhd1 (ARPKD) Gene Transcription and Renal Cystogenesis J. Biol. Chem., March 18, 2005; 280(11): 10578 - 10586. [Abstract] [Full Text] [PDF]

				T. Sakaguchi, X. Gu, H. M. Golden, E. Suh, D. B. Rhoads, and H.-C. Reinecker Cloning of the Human Claudin-2 5'-Flanking Region Revealed a TATA-less Promoter with Conserved Binding Sites in Mouse and Human for Caudal-related Homeodomain Proteins and Hepatocyte Nuclear Factor-1alpha J. Biol. Chem., June 7, 2002; 277(24): 21361 - 21370. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673