2008 JASN IMPACT FACTOR 7.505	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by FISCHBACH, M. Articles by HARALDSSON, B. Search for Related Content PubMed PubMed Citation Articles by FISCHBACH, M. Articles by HARALDSSON, B.

Dynamic Changes of the Total Pore Area Available for Peritoneal Exchange in Children

MICHEL FISCHBACH^* and BÖRJE HARALDSSON

^* Nephrology Dialysis Transplantation Children's Unit, Strasbourg, France
Departments of Nephrology and Physiology, Göteborg University, Gothenburg, Sweden.

Correspondence to Dr. Börje Haraldsson, Department of Nephrology, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden. Phone: +46-31-34-21701; Fax: +46-31-41-23-32; E-mail: borje.haraldsson{at}kidney.med.gu.se

Abstract. The most important of the parameters that describe exchange across the peritoneal membrane is the total pore area over diffusion distance (A₀/x). It determines the rate of diffusion and mainly seems to reflect the number of capillaries available for exchange. In the present study, a simplified three-pore analysis was used to estimate A₀/x from peritoneal equilibration tests. Two groups of children (mean age, 9.5 yr) who were on chronic peritoneal dialysis underwent studies with peritoneal equilibration tests. In the first group of children, three levels of fill volumes were used in each patient. In the second group of patients, the effects of posture and dwell time were analyzed from four consecutive peritoneal dialysis samples obtained after 15, 30, 60, and 90 min. As the fill volume was raised from 800 to 1400 ml/m² BSA, the steady-state A₀/x increased significantly by 21%, i.e., from 19,900 ± 1200 to 24,000 ± 1450 cm²/cm per 1.73 m² (n = 8). A further increase to 2000 ml/m² did not result in any change of A₀/x. Moreover, steady-state A₀/x fell significantly when the patients were standing, 21,900 ± 1400 compared with 29,400 ± 1330 cm²/cm per 1.73m² (n = 6) obtained in the supine position. There was a transient (<30 min) increase in A₀/x initially during the dwell, probably reflecting vasodilation and recruitment of capillaries. It is concluded that factors such as the intraperitoneal fill volume, posture, and dwell time all dynamically affect the total pore area available for exchange.

This article has been cited by other articles:

				M. Fischbach, C. Dheu, L. Seuge-Dargnies, and J. F. Delobbe ADEQUACY OF PERITONEAL DIALYSIS IN CHILDREN: CONSIDER THE MEMBRANE FOR OPTIMAL PRESCRIPTION Perit. Dial. Int., June 1, 2007; 27(Supplement_2): S167 - S170. [Abstract] [Full Text] [PDF]

				C. H. Schroder Optimal peritoneal dialysis: choice of volume and solution Nephrol. Dial. Transplant., April 1, 2004; 19(4): 782 - 784. [Full Text] [PDF]

				M. Fischbach, J. Terzic, S. Chauve, V. Laugel, A. Muller, and B. Haraldsson Effect of peritoneal dialysis fluid composition on peritoneal area available for exchange in children Nephrol. Dial. Transplant., April 1, 2004; 19(4): 925 - 932. [Abstract] [Full Text] [PDF]

				M. Fischbach, C. J. Stefanidis, and A. R. Watson Guidelines by an ad hoc European committee on adequacy of the paediatric peritoneal dialysis prescription Nephrol. Dial. Transplant., March 1, 2002; 17(3): 380 - 385. [Full Text] [PDF]

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673