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SBA-Positive Fibers between the CD Ampulla, Mesenchyme, and Renal Capsule

Karl Schumacher^*, Raimund Strehl^*, Uwe de Vries^*, Hermann Josef Groene and Will W. Minuth^*

*Department of Anatomy, University of Regensburg, Regensburg, Germany; Department of Cellular and Molecular Pathology, DKFZ, Heidelberg, Germany.

Correspondence to Dr. Karl Schumacher, University of Regensburg, Department of Anatomy, Universitätsstrasse 31, D-93053 Regensburg, Germany. Phone: 49-941-943-2875; Fax: 49-941-943-2868;

ABSTRACT. During kidney development, the CD shows two peculiarities. First, the tip of the CD ampulla is always found at a specific distance from the organ capsule. Second, the CD growth occurs as a perfectly straight elongation. It is unknown whether the CD-specific growth is dependent on hormonal action or on structural elements. Histochemical experiments on neonatal rabbit kidney yielded new insight into the interface of the CD ampulla and the surrounding nephrogenic mesenchyme. Incubation of tissue sections with soybean lectin (SBA) showed the existence of fibers extending in a radial course from the ampullar tip through the mesenchyme toward the organ capsule. SBA labeling did not colocalize with collagen type I, III, IV, V, and VI, laminin, fibronectin, and tenascin. It is assumed that while the kidney increases in volume the structural fixation of the ampullar tip by the SBA-positive fibers causes CD ampullae to maintain a constant distance from the organ capsule. The connection would explain the linear extension of the CD in relation to the organ capsule. In addition, the presented data suggest that the SBA-positive fibers between ampullar tip and organ capsule create a structural microcompartmentation of the nephrogenic zone. E-mail: karl.schumacher@vkl.uni-regensburg.de

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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673