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J Am Soc Nephrol 13:2969-2973, 2002
© 2002 American Society of Nephrology

Access Flow Monitoring of Patients with Native Vessel Arteriovenous Fistulae and Previous Angioplasty

Marcello Tonelli*, David Hirsch{dagger}{ddagger}, Timothy W.I. Clark§, Colleen Wile{dagger}, Paula Mossop{dagger}, Joanne Marryatt{dagger} and Kailash Jindal{dagger}{ddagger}

*Department of Medicine, University of Alberta, Edmonton, Canada; {dagger}Department of Medicine, Dalhousie University, Halifax, Canada; {ddagger}Queen Elizabeth II Health Sciences Centre, Halifax, Canada; and §Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.

Correspondence to Dr. Jindal, Room 5076, Dickson Building, 5820 University Avenue, Halifax, Nova Scotia, B3H 1V8, Canada. Phone: 902-473-2662; Fax: 902-473-2675;E-mail: kjindal{at}is.dal.ca

ABSTRACT. Screening strategies based on measurement of access blood flow (Qa) allow detection and angioplasty of subclinical stenosis in native vessel arteriovenous (AV) fistulae. However, little is known about the efficacy of Qa measurements for detecting recurrent stenoses in fistulae and that of angioplasty for correcting them. A total of 303 patients were studied over 30 mo; 69 (23%) of these had stenoses, of whom 53 underwent angioplasty. Of those undergoing angioplasty, 30 patients had 46 episodes of recurrent positive studies and underwent repeat fistulography. In 31 of these episodes (19 patients), stenosis was again identified and treated successfully with angioplasty. Overall positive predictive values for stenosis were similar in first and subsequent episodes of stenosis (71% versus 67%), and angioplasty was associated with sustained increases in Qa for both first and subsequent episodes. Assisted patency in fistulae that required repeat angioplasty was 87% (median follow-up 10 mo after the second angioplasty). In conclusion, Qa is effective for detecting first and subsequent lesions in patients with AV fistulae, and angioplasty of first or subsequent lesions is associated with sustained increments in Qa. Continued screening after correction of first stenoses appears reasonable, because of both the frequency of recurrent stenosis and the success of repeat intervention.




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