Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Aubel, R. A. M. H.
Right arrow Articles by Russel, F. G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Aubel, R. A. M. H.
Right arrow Articles by Russel, F. G. M.
J Am Soc Nephrol 13:595-603, 2002
© 2002 American Society of Nephrology

The MRP4/ABCC4 Gene Encodes a Novel Apical Organic Anion Transporter in Human Kidney Proximal Tubules: Putative Efflux Pump for Urinary cAMP and cGMP

Rémon A. M. H. van Aubel*, Pascal H. E. Smeets*, Janny G. P. Peters*, René J. M. Bindels{dagger} and Frans G. M. Russel*

Departments of *Pharmacology and Toxicology and {dagger}Cell Physiology, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands.

Correspondence to Dr. Frans G. M. Russel, Department of Pharmacology and Toxicology 233, Nijmegen Center for Molecular Life Sciences, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: +31-24-3613691/3616892; Fax: +31-24-3614214; E-mail: F.Russel{at}farm.kun.nl

ABSTRACT. The cyclic nucleotides cAMP and cGMP play key roles in cellular signaling and the extracellular regulation of fluid balance. In the kidney, cAMP is excreted across the apical proximal tubular membrane into urine, where it reduces phosphate reabsorption through a dipyridamole-sensitive mechanism that is not fully understood. It has long been known that this cAMP efflux pathway is dependent on ATP and is inhibited by probenecid. However, its identity and whether cGMP shares the same transporter have not been established. Here the expression, localization, and functional properties of human multidrug resistance protein 4 (MRP4) are reported. MRP4 is localized to the proximal tubule apical membrane of human kidney, and membrane vesicles from Sf9 cells expressing human MRP4 exhibit ATP-dependent transport of [3H]cAMP and [3H]cGMP. Both probenecid and dipyridamole are potent MRP4 inhibitors. ATP-dependent [3H]methotrexate and [3H]estradiol-17ß-D-glucuronide transport by MRP4 and interactions with the anionic conjugates S-(2,4-dinitrophenyl)-glutathione, N-acetyl-(2,4-dinitrophenyl)-cysteine, {alpha}-naphthyl-ß-D-glucuronide, and p-nitrophenyl-ß-D-glucuronide are also demonstrated. In kidneys of rats deficient in the apical anionic conjugate efflux pump Mrp2, Mrp4 expression is maintained at the same level. It is concluded that MRP4 is a novel apical organic anion transporter and the putative efflux pump for cAMP and cGMP in human kidney proximal tubules.




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
Y. Kitamura, M. Hirouchi, H. Kusuhara, J. D. Schuetz, and Y. Sugiyama
Increasing Systemic Exposure of Methotrexate by Active Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3)
J. Pharmacol. Exp. Ther., November 1, 2008; 327(2): 465 - 473.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. A. K. El-Sheikh, J. J. M. W. van den Heuvel, E. Krieger, F. G. M. Russel, and J. B. Koenderink
Functional Role of Arginine 375 in Transmembrane Helix 6 of Multidrug Resistance Protein 4 (MRP4/ABCC4)
Mol. Pharmacol., October 1, 2008; 74(4): 964 - 971.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
L. M. Aleksunes, Y. Cui, and C. D. Klaassen
Prominent Expression of Xenobiotic Efflux Transporters in Mouse Extraembryonic Fetal Membranes Compared with Placenta
Drug Metab. Dispos., September 1, 2008; 36(9): 1960 - 1970.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
C. C. Bridges, L. Joshee, and R. K. Zalups
MRP2 and the DMPS- and DMSA-Mediated Elimination of Mercury in TR- and Control Rats Exposed to Thiol S-Conjugates of Inorganic Mercury
Toxicol. Sci., September 1, 2008; 105(1): 211 - 220.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
W. Silverman, S. Locovei, and G. Dahl
Probenecid, a gout remedy, inhibits pannexin 1 channels
Am J Physiol Cell Physiol, September 1, 2008; 295(3): C761 - C767.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
C. de Wolf, R. Jansen, H. Yamaguchi, M. de Haas, K. van de Wetering, J. Wijnholds, J. Beijnen, and P. Borst
Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides
Mol. Cancer Ther., September 1, 2008; 7(9): 3092 - 3102.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Md. T. Hoque and S. P.C. Cole
Down-regulation of Na+/H+ Exchanger Regulatory Factor 1 Increases Expression and Function of Multidrug Resistance Protein 4
Cancer Res., June 15, 2008; 68(12): 4802 - 4809.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
N. Abla, L. W. Chinn, T. Nakamura, L. Liu, C. C. Huang, S. J. Johns, M. Kawamoto, D. Stryke, T. R. Taylor, T. E. Ferrin, et al.
The Human Multidrug Resistance Protein 4 (MRP4, ABCC4): Functional Analysis of a Highly Polymorphic Gene
J. Pharmacol. Exp. Ther., June 1, 2008; 325(3): 859 - 868.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Matsushima, K. Maeda, H. Hayashi, Y. Debori, A. H. Schinkel, J. D. Schuetz, H. Kusuhara, and Y. Sugiyama
Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine
Mol. Pharmacol., May 1, 2008; 73(5): 1474 - 1483.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
J. M. Evans, J. P. Day, P. Cabrero, J. A. T. Dow, and S.-A. Davies
A new role for a classical gene: White transports cyclic GMP
J. Exp. Biol., March 15, 2008; 211(6): 890 - 899.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Rius, J. Hummel-Eisenbeiss, and D. Keppler
ATP-Dependent Transport of Leukotrienes B4 and C4 by the Multidrug Resistance Protein ABCC4 (MRP4)
J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 86 - 94.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. C. Bridges, L. Joshee, and R. K. Zalups
Multidrug Resistance Proteins and the Renal Elimination of Inorganic Mercury Mediated by 2,3-Dimercaptopropane-1-Sulfonic Acid and Meso-2,3-dimercaptosuccinic Acid
J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 383 - 390.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
Y. Tanaka, C. Chen, J. M. Maher, and C. D. Klaassen
Ischemia-Reperfusion of Rat Livers Decreases Liver and Increases Kidney Multidrug Resistance Associated Protein 2 (Mrp2)
Toxicol. Sci., January 1, 2008; 101(1): 171 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Z. P. Lin, Y.-L. Zhu, D. R. Johnson, K. P. Rice, T. Nottoli, B. C. Hains, J. McGrath, S. G. Waxman, and A. C. Sartorelli
Disruption of cAMP and Prostaglandin E2 Transport by Multidrug Resistance Protein 4 Deficiency Alters cAMP-Mediated Signaling and Nociceptive Response
Mol. Pharmacol., January 1, 2008; 73(1): 243 - 251.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Reichel, R. Masereeuw, J. J. M. W. van den Heuvel, D. S. Miller, and G. Fricker
Transport of a fluorescent cAMP analog in teleost proximal tubules
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2382 - R2389.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
N. Mizuno, T. Takahashi, H. Kusuhara, J. D. Schuetz, T. Niwa, and Y. Sugiyama
Evaluation of the Role of Breast Cancer Resistance Protein (BCRP/ABCG2) and Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in The Urinary Excretion of Sulfate and Glucuronide Metabolites of Edaravone (MCI-186; 3-Methyl-1-phenyl-2-pyrazolin-5-one)
Drug Metab. Dispos., November 1, 2007; 35(11): 2045 - 2052.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
N. A. Wolff, B. C. Burckhardt, G. Burckhardt, M. Oellerich, and V. W. Armstrong
Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney
Nephrol. Dial. Transplant., September 1, 2007; 22(9): 2497 - 2503.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
N. Mizuno, T. Takahashi, Y. Iwase, H. Kusuhara, T. Niwa, and Y. Sugiyama
Human Organic Anion Transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) Transport Edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and Its Sulfate Conjugate
Drug Metab. Dispos., August 1, 2007; 35(8): 1429 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
L. Ci, H. Kusuhara, M. Adachi, J. D. Schuetz, K. Takeuchi, and Y. Sugiyama
Involvement of MRP4 (ABCC4) in the Luminal Efflux of Ceftizoxime and Cefazolin in the Kidney
Mol. Pharmacol., June 1, 2007; 71(6): 1591 - 1597.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
H. Huang and G. G. Haddad
Drosophila dMRP4 regulates responsiveness to O2 deprivation and development under hypoxia
Physiol Genomics, May 11, 2007; 29(3): 260 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
T. Imaoka, H. Kusuhara, M. Adachi, J. D. Schuetz, K. Takeuchi, and Y. Sugiyama
Functional Involvement of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) in the Renal Elimination of the Antiviral Drugs Adefovir and Tenofovir
Mol. Pharmacol., February 1, 2007; 71(2): 619 - 627.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. G. Belinsky, P. Guo, K. Lee, F. Zhou, E. Kotova, A. Grinberg, H. Westphal, I. Shchaveleva, A. Klein-Szanto, J. M. Gallo, et al.
Multidrug Resistance Protein 4 Protects Bone Marrow, Thymus, Spleen, and Intestine from Nucleotide Analogue-Induced Damage
Cancer Res., January 1, 2007; 67(1): 262 - 268.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
A. A. K. El-Sheikh, J. J. M. W. van den Heuvel, J. B. Koenderink, and F. G. M. Russel
Interaction of Nonsteroidal Anti-Inflammatory Drugs with Multidrug Resistance Protein (MRP) 2/ABCC2- and MRP4/ABCC4-Mediated Methotrexate Transport
J. Pharmacol. Exp. Ther., January 1, 2007; 320(1): 229 - 235.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. K. Jackson, Z. Mi, and R. K. Dubey
The Extracellular cAMP-Adenosine Pathway Significantly Contributes to the in Vivo Production of Adenosine
J. Pharmacol. Exp. Ther., January 1, 2007; 320(1): 117 - 123.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Hasegawa, H. Kusuhara, M. Adachi, J. D. Schuetz, K. Takeuchi, and Y. Sugiyama
Multidrug Resistance-Associated Protein 4 Is Involved in the Urinary Excretion of Hydrochlorothiazide and Furosemide
J. Am. Soc. Nephrol., January 1, 2007; 18(1): 37 - 45.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. J. Zamek-Gliszczynski, K.-i. Nezasa, X. Tian, A. S. Bridges, K. Lee, M. G. Belinsky, G. D. Kruh, and K. L. R. Brouwer
Evaluation of the Role of Multidrug Resistance-Associated Protein (Mrp) 3 and Mrp4 in Hepatic Basolateral Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Abcc3-/- and Abcc4-/- Mice
J. Pharmacol. Exp. Ther., December 1, 2006; 319(3): 1485 - 1491.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. S. Ray, T. Cihlar, K. L. Robinson, L. Tong, J. E. Vela, M. D. Fuller, L. M. Wieman, E. J. Eisenberg, and G. R. Rhodes
Mechanism of active renal tubular efflux of tenofovir.
Antimicrob. Agents Chemother., October 1, 2006; 50(10): 3297 - 3304.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Notenboom, A. C. Wouterse, B. Peters, L. H. Kuik, S. Heemskerk, F. G. M. Russel, and R. Masereeuw
Increased Apical Insertion of the Multidrug Resistance Protein 2 (MRP2/ABCC2) in Renal Proximal Tubules following Gentamicin Exposure
J. Pharmacol. Exp. Ther., September 1, 2006; 318(3): 1194 - 1202.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
F. M. van de Water, O. C. Boerman, A. C. Wouterse, J. G. P. Peters, F. G. M. Russel, and R. Masereeuw
INTRAVENOUSLY ADMINISTERED SHORT INTERFERING RNA ACCUMULATES IN THE KIDNEY AND SELECTIVELY SUPPRESSES GENE FUNCTION IN RENAL PROXIMAL TUBULES
Drug Metab. Dispos., August 1, 2006; 34(8): 1393 - 1397.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. G. Deeley, C. Westlake, and S. P. C. Cole
Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins.
Physiol Rev, July 1, 2006; 86(3): 849 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
S. Dallas, D. S. Miller, and R. Bendayan
Multidrug resistance-associated proteins: expression and function in the central nervous system.
Pharmacol. Rev., June 1, 2006; 58(2): 140 - 161.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. K. Jackson, L. C. Zacharia, M. Zhang, D. G. Gillespie, C. Zhu, and R. K. Dubey
cAMP-Adenosine Pathway in the Proximal Tubule
J. Pharmacol. Exp. Ther., June 1, 2006; 317(3): 1219 - 1229.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
X.-Y. Chu, J. R. Strauss, M. A. Mariano, J. Li, D. J. Newton, X. Cai, R. W. Wang, J. Yabut, D. P. Hartley, D. C. Evans, et al.
Characterization of Mice Lacking the Multidrug Resistance Protein Mrp2 (Abcc2)
J. Pharmacol. Exp. Ther., May 1, 2006; 317(2): 579 - 589.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
G. Zollner, M. Wagner, T. Moustafa, P. Fickert, D. Silbert, J. Gumhold, A. Fuchsbichler, E. Halilbasic, H. Denk, H.-U. Marschall, et al.
Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-{alpha}/beta in the adaptive response to bile acids
Am J Physiol Gastrointest Liver Physiol, May 1, 2006; 290(5): G923 - G932.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Rius, J. Hummel-Eisenbeiss, A. F. Hofmann, and D. Keppler
Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione
Am J Physiol Gastrointest Liver Physiol, April 1, 2006; 290(4): G640 - G649.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
I. S. Westley, L. R. Brogan, R. G. Morris, A. M. Evans, and B. C. Sallustio
ROLE OF MRP2 IN THE HEPATIC DISPOSITION OF MYCOPHENOLIC ACID AND ITS GLUCURONIDE METABOLITES: EFFECT OF CYCLOSPORINE
Drug Metab. Dispos., February 1, 2006; 34(2): 261 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. Sekine, H. Miyazaki, and H. Endou
Molecular physiology of renal organic anion transporters
Am J Physiol Renal Physiol, February 1, 2006; 290(2): F251 - F261.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. Miyazaki, N. Anzai, S. Ekaratanawong, T. Sakata, H. J. Shin, P. Jutabha, T. Hirata, X. He, H. Nonoguchi, K. Tomita, et al.
Modulation of Renal Apical Organic Anion Transporter 4 Function by Two PDZ Domain-Containing Proteins
J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3498 - 3506.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
N. Anzai, P. Jutabha, A. Enomoto, H. Yokoyama, H. Nonoguchi, T. Hirata, K. Shiraya, X. He, S. H. Cha, M. Takeda, et al.
Functional Characterization of Rat Organic Anion Transporter 5 (Slc22a19) at the Apical Membrane of Renal Proximal Tubules
J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 534 - 544.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Notenboom, D. S. Miller, L. H. Kuik, P. Smits, F. G. M. Russel, and R. Masereeuw
Short-Term Exposure of Renal Proximal Tubules to Gentamicin Increases Long-Term Multidrug Resistance Protein 2 (Abcc2) Transport Function and Reduces Nephrotoxicant Sensitivity
J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 912 - 920.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
J. M. Maher, A. L. Slitt, N. J. Cherrington, X. Cheng, and C. D. Klaassen
TISSUE DISTRIBUTION AND HEPATIC AND RENAL ONTOGENY OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) FAMILY IN MICE
Drug Metab. Dispos., July 1, 2005; 33(7): 947 - 955.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Wielinga, J. H. Hooijberg, S. Gunnarsdottir, I. Kathmann, G. Reid, N. Zelcer, K. van der Born, M. de Haas, I. van der Heijden, G. Kaspers, et al.
The Human Multidrug Resistance Protein MRP5 Transports Folates and Can Mediate Cellular Resistance against Antifolates
Cancer Res., May 15, 2005; 65(10): 4425 - 4430.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
M. A. Hediger, R. J Johnson, H. Miyazaki, and H. Endou
Molecular Physiology of Urate Transport
Physiology, April 1, 2005; 20(2): 125 - 133.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. D. Norris, J. Smith, K. Tanabe, P. Tobin, C. Flemming, G. L. Scheffer, P. Wielinga, S. L. Cohn, W. B. London, G. M. Marshall, et al.
Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro
Mol. Cancer Ther., April 1, 2005; 4(4): 547 - 553.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J Wolf, T Stranzl, M Filipits, G Pohl, R Pirker, B Leeb, and J S Smolen
Expression of resistance markers to methotrexate predicts clinical improvement in patients with rheumatoid arthritis
Ann Rheum Dis, April 1, 2005; 64(4): 564 - 568.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Z.-S. Chen, Y. Guo, M. G. Belinsky, E. Kotova, and G. D. Kruh
Transport of Bile Acids, Sulfated Steroids, Estradiol 17-{beta}-D-Glucuronide, and Leukotriene C4 by Human Multidrug Resistance Protein 8 (ABCC11)
Mol. Pharmacol., February 1, 2005; 67(2): 545 - 557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. A. M. H. Van Aubel, P. H. E. Smeets, J. J. M. W. van den Heuvel, and F. G. M. Russel
Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
Am J Physiol Renal Physiol, February 1, 2005; 288(2): F327 - F333.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
Y.-J. Lee, H. Kusuhara, J. W. Jonker, A. H. Schinkel, and Y. Sugiyama
Investigation of Efflux Transport of Dehydroepiandrosterone Sulfate and Mitoxantrone at the Mouse Blood-Brain Barrier: A Minor Role of Breast Cancer Resistance Protein
J. Pharmacol. Exp. Ther., January 1, 2005; 312(1): 44 - 52.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Jedlitschky, K. Tirschmann, L. E. Lubenow, H. K. Nieuwenhuis, J. W. N. Akkerman, A. Greinacher, and H. K. Kroemer
The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage
Blood, December 1, 2004; 104(12): 3603 - 3610.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
Y. Zhang, J. D. Schuetz, W. F. Elmquist, and D. W. Miller
Plasma Membrane Localization of Multidrug Resistance-Associated Protein Homologs in Brain Capillary Endothelial Cells
J. Pharmacol. Exp. Ther., November 1, 2004; 311(2): 449 - 455.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
P. H.E. Smeets, R. A.M.H. van Aubel, A. C. Wouterse, J. J.M.W. van den Heuvel, and F. G.M. Russel
Contribution of Multidrug Resistance Protein 2 (MRP2/ABCC2) to the Renal Excretion of p-aminohippurate (PAH) and Identification of MRP4 (ABCC4) as a Novel PAH Transporter
J. Am. Soc. Nephrol., November 1, 2004; 15(11): 2828 - 2835.
[Abstract] [Full Text] [PDF]

Home page
 Drug Metab. Dispos.Home page
N. Mizuno, M. Suzuki, H. Kusuhara, H. Suzuki, K. Takeuchi, T. Niwa, J. W. Jonker, and Y. Sugiyama
IMPAIRED RENAL EXCRETION OF 6-HYDROXY-5,7-DIMETHYL-2-METHYLAMINO-4-(3-PYRIDYLMETHYL) BENZOTHIAZOLE (E3040) SULFATE IN BREAST CANCER RESISTANCE PROTEIN (BCRP1/ABCG2) KNOCKOUT MICE
Drug Metab. Dispos., September 1, 2004; 32(9): 898 - 901.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Leggas, M. Adachi, G. L. Scheffer, D. Sun, P. Wielinga, G. Du, K. E. Mercer, Y. Zhuang, J. C. Panetta, B. Johnston, et al.
Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy
Mol. Cell. Biol., September 1, 2004; 24(17): 7612 - 7621.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
T. Imaoka, H. Kusuhara, S. Adachi-Akahane, M. Hasegawa, N. Morita, H. Endou, and Y. Sugiyama
The Renal-Specific Transporter Mediates Facilitative Transport of Organic Anions at the Brush Border Membrane of Mouse Renal Tubules
J. Am. Soc. Nephrol., August 1, 2004; 15(8): 2012 - 2022.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. H. Wright and W. H. Dantzler
Molecular and Cellular Physiology of Renal Organic Cation and Anion Transport
Physiol Rev, July 1, 2004; 84(3): 987 - 1049.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Notenboom, D. S. Miller, P. Smits, F. G. M. Russel, and R. Masereeuw
Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule
Am J Physiol Renal Physiol, July 1, 2004; 287(1): F33 - F38.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Dallas, L. Schlichter, and R. Bendayan
Multidrug Resistance Protein (MRP) 4- and MRP 5-Mediated Efflux of 9-(2-Phosphonylmethoxyethyl)adenine by Microglia
J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 1221 - 1229.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. W. Beyenbach
Kidneys sans glomeruli
Am J Physiol Renal Physiol, May 1, 2004; 286(5): F811 - F827.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
H. Hasannejad, M. Takeda, K. Taki, H. J. Shin, E. Babu, P. Jutabha, S. Khamdang, M. Aleboyeh, M. L. Onozato, A. Tojo, et al.
Interactions of Human Organic Anion Transporters with Diuretics
J. Pharmacol. Exp. Ther., March 1, 2004; 308(3): 1021 - 1029.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Kneuer, K. U. Honscha, and W. Honscha
Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization
Am J Physiol Renal Physiol, March 1, 2004; 286(3): F564 - F571.
[Abstract] [Full Tex