2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Poulsom, R. Articles by Wright, N. A. Search for Related Content PubMed PubMed Citation Articles by Poulsom, R. Articles by Wright, N. A.

Bone Marrow Stem Cells Contribute to Healing of the Kidney

Richard Poulsom^*, Malcolm R. Alison, Terry Cook, Rosemary Jeffery^*, Eoin Ryan^*, Stuart J. Forbes, Toby Hunt^*, Susannah Wyles^* and Nicholas A. Wright^*,

*Histopathology Unit, Cancer Research UK, London Research Institute, London, United Kingdom; Department of Histopathology, Imperial College, Hammersmith Campus, London, United Kingdom; Department of Medicine, Faculty of Medicine, Imperial College, St. Mary’s Hospital, London, United Kingdom; and Bart’s and the Royal London Hospitals, Queen Mary College, London, United Kingdom.

Correspondence to Prof. Richard Poulsom, Histopathology Unit, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, London, WC2A 3PX, UK; Phone: +44-(0)-20-7269-3538; Fax: +44-(0)-20-7269-3491;

ABSTRACT. A variety of recent studies support the existence of pathways, in adult humans and rodents, that allow adult stem cells to be surprisingly flexible in their differentiation repertoires. Termed plasticity, this property allows adult stem cells, assumed until now to be committed to generating a fixed range of progeny, on relocation to switch to make other specialized sets of cells appropriate to their new niche. Cells normally present within the bone marrow seem particularly flexible and are able to contribute usefully to many recipient organs. In studies of the liver, bone marrow–derived cells are seen with specialized structural and metabolic adaptations commensurate with their new locations, and these may be abundant, even sufficient, to rescue recipient mice from genetic defects and with evidence that they have proliferated in situ. In the kidney, several studies provide evidence for the presence of "reprogrammed" cells, but in most, it remains possible that cells arrive and redifferentiate but are no longer stem cells. Nevertheless, that appropriately differentiated cells are delivered deep within organs simply by injection of bone marrow cells should make us think differently about the way organs regenerate and repair. Migratory pathways for multipotential cells could be exploited to effect repairs using an individual’s own stem cells, perhaps after gene therapy. This concept makes it clear that a transplanted organ would in time become affected by the genetic susceptibilities of the recipient, because of phenotypes that are expressed when trafficking cells incorporate and differentiate. E-mail: richard.poulsom@cancer.org.uk

This article has been cited by other articles:

				M. Huls, F. G. M. Russel, and R. Masereeuw The Role of ATP Binding Cassette Transporters in Tissue Defense and Organ Regeneration J. Pharmacol. Exp. Ther., January 1, 2009; 328(1): 3 - 9. [Abstract] [Full Text] [PDF]

				D. Vansthertem, N. Caron, A.-E. Decleves, S. Cludts, A. Gossiaux, D. Nonclercq, B. Flamion, A. Legrand, and G. Toubeau Label-retaining cells and tubular regeneration in postischaemic kidney Nephrol. Dial. Transplant., December 1, 2008; 23(12): 3786 - 3797. [Abstract] [Full Text] [PDF]

				F. Togel, Y. Yang, P. Zhang, Z. Hu, and C. Westenfelder Bioluminescence imaging to monitor the in vivo distribution of administered mesenchymal stem cells in acute kidney injury Am J Physiol Renal Physiol, July 1, 2008; 295(1): F315 - F321. [Abstract] [Full Text] [PDF]

				R. Poulsom, E. I. Prodromidi, C. D. Pusey, and H. T. Cook Cell therapy for renal regeneration--time for some joined-up thinking? Nephrol. Dial. Transplant., December 1, 2006; 21(12): 3349 - 3353. [Full Text] [PDF]

				J.J. Mao, W.V. Giannobile, J.A. Helms, S.J. Hollister, P.H. Krebsbach, M.T. Longaker, and S. Shi Craniofacial tissue engineering by stem cells. J. Dent. Res., November 1, 2006; 85(11): 966 - 979. [Abstract] [Full Text] [PDF]

				J.J. Mao, W.V. Giannobile, J.A. Helms, S.J. Hollister, P.H. Krebsbach, M.T. Longaker, and S. Shi Craniofacial Tissue Engineering by Stem Cells Journal of Dental Research, November 1, 2006; 85(11): 966 - 979. [Abstract] [Full Text] [PDF]

				M. Karl, M. Berho, J. Pignac-Kobinger, G. E. Striker, and S. J. Elliot Differential Effects of Continuous and Intermittent 17{beta}-Estradiol Replacement and Tamoxifen Therapy on the Prevention of Glomerulosclerosis: Modulation of the Mesangial Cell Phenotype in Vivo Am. J. Pathol., August 1, 2006; 169(2): 351 - 361. [Abstract] [Full Text] [PDF]

				A. Leri, J. Kajstura, and P. Anversa Cardiac Stem Cells and Mechanisms of Myocardial Regeneration Physiol Rev, October 1, 2005; 85(4): 1373 - 1416. [Abstract] [Full Text] [PDF]

				A. Shimizu, Y. Masuda, T. Mori, H. Kitamura, M. Ishizaki, Y. Sugisaki, and Y. Fukuda Vascular Endothelial Growth Factor165 Resolves Glomerular Inflammation and Accelerates Glomerular Capillary Repair in Rat Anti-Glomerular Basement Membrane Glomerulonephritis J. Am. Soc. Nephrol., October 1, 2004; 15(10): 2655 - 2665. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673