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Genomic Strategies for Diabetic Nephropathy

Katalin Susztak^*, Kumar Sharma, Mario Schiffer^*, Peter McCue, Emilio Ciccone and Erwin P. Böttinger^*,

*Department of Medicine, Division of Nephrology, and Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York; and Department of Medicine, Division of Nephrology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Correspondence to Dr. Katalin Susztak, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. Phone: 718-430-3616; Fax: 718-430-2732; www.aecom.yu.edu/BottingerLab/

ABSTRACT. Insight into the molecular mechanisms that underlie the origin and progression of diabetic nephropathy remains limited in part because conventional research tools have restricted investigators to focus on single genes or isolated pathways. Microarray technologies provide opportunities for evaluating genetic factors and environmental effects at a genomic scale during the pathogenesis of diabetic nephropathy. Despite the enormous power of the microarray technology, there are several pitfalls that need to be considered. This article discusses conceptual, practical, statistical, and logistical considerations for the use of microarrays in studies of experimental and human diabetic renal disease. New knowledge in this field will facilitate new approaches for molecular diagnosis and drug discovery. E-mail: ksusztak@aecom.yu.edu

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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673