Journal of the American Society of Nephrology
2008 JASN IMPACT FACTOR 7.505 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zoccali, C.
Right arrow Articles by Malatino, L. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zoccali, C.
Right arrow Articles by Malatino, L. S.
J Am Soc Nephrol 15:1029-1037, 2004
© 2004 American Society of Nephrology

CLINICAL SCIENCE

Prognostic Value of Echocardiographic Indicators of Left Ventricular Systolic Function in Asymptomatic Dialysis Patients

Carmine Zoccali*, Francesco A. Benedetto{dagger}, Francesca Mallamaci*, Giovanni Tripepi*, Giuseppe Giacone{ddagger}, Alessandro Cataliotti{ddagger}, Giuseppe Seminara{ddagger}, Benedetta Stancanelli{ddagger} and Lorenzo S. Malatino{ddagger}

*CNR-IBIM National Research Council, Institute of Biomedicine, Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Reggio Calabria, Italy; {dagger}Cardiology Unit, Morelli Hospital, Reggio Calabira, Italy; {ddagger}Institute of Internal Medicine "L. Condorelli," Catania University, Catania, Italy.

Correspondence to Dr. Carmine Zoccali, Professor, CNR-IBIM Consiglio Nazionale delle Ricerche, Istituto di Biomedicina, Epidemiologia Clinica e Fisiopatologia, delle Malattie Renali e dell’Ipertensione Arteriosa, c/o Divisione di Nefrologia e Dialisi, Ospedali Riuniti Via Vallone Petrara, 89124, Reggio Calabria, Italy. Phone: 39-0965-397010; Fax: 39-0965-397000; E-mail: carmine.zoccali{at}tin.it

ABSTRACT. Patients with end-stage renal disease (ESRD) are at high risk for heart failure, but the prevalence and the prognostic value of asymptomatic systolic dysfunction in these patients are unknown. In this prospective cohort study, the authors have therefore assessed by echocardiography the prevalence and the prognostic value of systolic function as estimated by ejection fraction (EF), fractional shortening at endocardial level (endoFS), and at midwall (mwFS), in a cohort of 254 asymptomatic dialysis patients. Systolic dysfunction had a prevalence rate of 26% by endoFS and of 48% by mwFS. During the follow-up period, 125 patients had one or more fatal and nonfatal CV events. On multivariate COX regression analysis, the three LV systolic function indicators were independently associated with incident fatal and nonfatal CV events, and there were no differences in the predictive power of these indicators (P > 0.30). The prediction power of LV function indicators was largely independent of traditional and novel risk factors in ESRD such as C-reactive protein and asymmetric dimethyl arginine (ADMA). ADMA was significantly related with LV function indicators as well as with mortality and incident CV events, but these links were much reduced (P = NS) in models including LV function indicators. Of note, the risk of CV events was minimal in patients with normal LV mass and function, intermediate in patients with either LVH or systolic dysfunction, and maximal in patients displaying both alterations. The study of myocardial contractility by echocardiography provides prognostic information independently of LV mass and other risk factors in ESRD. Risk stratification by simple systolic function parameters may prove useful in secondary prevention strategies in these patients.




This article has been cited by other articles:


Home page
 CJASNHome page
R. J. Glassock, R. Pecoits-Filho, and S. H. Barberato
Left Ventricular Mass in Chronic Kidney Disease and ESRD
Clin. J. Am. Soc. Nephrol., December 1, 2009; 4(Supplement_1): S79 - S91.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
W. L. Henrich
Optimal Cardiovascular Therapy for Patients with ESRD over the Next Several Years
Clin. J. Am. Soc. Nephrol., December 1, 2009; 4(Supplement_1): S106 - S109.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
J. O. Burton, H. J. Jefferies, N. M. Selby, and C. W. McIntyre
Hemodialysis-Induced Cardiac Injury: Determinants and Associated Outcomes
Clin. J. Am. Soc. Nephrol., May 1, 2009; 4(5): 914 - 920.
[Abstract] [Full Text] [PDF]

Home page
 NDT PlusHome page
C. W. McIntyre, S. G. John, and H. J. Jefferies
Advances in the cardiovascular assessment of patients with chronic kidney disease
NDT Plus, December 1, 2008; 1(6): 383 - 391.
[Abstract] [Full Text] [PDF]

Home page
 NDT PlusHome page
M. M. Sood, R. P. Pauly, C. Rigatto, and P. Komenda
Left ventricular dysfunction in the haemodialysis population
NDT Plus, August 1, 2008; 1(4): 199 - 205.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. Zoccali, F. Mallamaci, F. A. Benedetto, G. Tripepi, P. Pizzini, S. Cutrupi, and L. Malatino
Urotensin II and Cardiomyopathy in End-Stage Renal Disease
Hypertension, February 1, 2008; 51(2): 326 - 333.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
D. Banerjee, J. Z. Ma, A. J. Collins, and C. A. Herzog
Long-Term Survival of Incident Hemodialysis Patients Who Are Hospitalized for Congestive Heart Failure, Pulmonary Edema, or Fluid Overload
Clin. J. Am. Soc. Nephrol., November 1, 2007; 2(6): 1186 - 1190.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
D. Hernandez, A. Gonzalez, M. Rufino, I. Laynez, A. de la Rosa, E. Porrini, J. Lacalzada, A. Barragan, V. Lorenzo, and A. Torres
Time-dependent changes in cardiac growth after kidney transplantation: the impact of pre-dialysis ventricular mass
Nephrol. Dial. Transplant., September 1, 2007; 22(9): 2678 - 2685.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
R. Sharma, E. Chemla, M. Tome, R. L Mehta, H. Gregson, S. J D Brecker, R. Chang, and D. Pellerin
Echocardiography-based score to predict outcome after renal transplantation
Heart, April 1, 2007; 93(4): 464 - 469.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
G. Tripepi, F. A. Benedetto, F. Mallamaci, R. Tripepi, L. Malatino, and C. Zoccali
Left Atrial Volume Monitoring and Cardiovascular Risk in Patients with End-Stage Renal Disease: A Prospective Cohort Study
J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1316 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. Zoccali, F. A. Benedetto, G. Tripepi, F. Mallamaci, F. Rapisarda, G. Seminara, G. Bonanno, and L. S. Malatino
Left Ventricular Systolic Function Monitoring in Asymptomatic Dialysis Patients: A Prospective Cohort Study
J. Am. Soc. Nephrol., May 1, 2006; 17(5): 1460 - 1465.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
T. Berl and W. Henrich
Kidney-Heart Interactions: Epidemiology, Pathogenesis, and Treatment
Clin. J. Am. Soc. Nephrol., January 1, 2006; 1(1): 8 - 18.
[Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673