 |
||||
| 2007 JASN IMPACT FACTOR 7.111 | HOME AUTHOR INFO EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP | |||
| CURRENT ISSUE | ARCHIVES | JASN Express | ONLINE SUBMISSION | |
|
||||
| 2007 JASN IMPACT FACTOR 7.111 | HOME AUTHOR INFO EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP | |||
| CURRENT ISSUE | ARCHIVES | JASN Express | ONLINE SUBMISSION | |
BASIC SCIENCE |
*Department of Experimental Medicine and Nephrology, Anthony Raine Laboratory and William Harvey Research Institute, St. Bartholomew’s and the Royal London School of Medicine, Queen Mary College, University of London, London, United Kingdom; Department of Pathology, University Medical Buildings, Aberdeen, Scotland, United Kingdom; Laboratory of Pharmacology, University of Lisbon, Lisbon, Portugal; and Department of Pathology, Royal London Hospital, London, United Kingdom
Correspondence to Dr. Edward J. Sharples, Department of Experimental Medicine and Nephrology, William Harvey Research Institute, John Vane Science Block, Charterhouse Square, London. Phone: 02007377480; Fax: 02073777003; E-mail: edsharps{at}doctors.org.uk
ABSTRACT. Erythropoietin (EPO) is upregulated by hypoxia and causes proliferation and differentiation of erythroid progenitors in the bone marrow through inhibition of apoptosis. EPO receptors are expressed in many tissues, including the kidney. Here it is shown that a single systemic administration of EPO either preischemia or just before reperfusion prevents ischemia-reperfusion injury in the rat kidney. Specifically, EPO (300 U/kg) reduced glomerular dysfunction and tubular injury (biochemical and histologic assessment) and prevented caspase-3, -8, and -9 activation in vivo and reduced apoptotic cell death. In human (HK-2) proximal tubule epithelial cells, EPO attenuated cell death in response to oxidative stress and serum starvation. EPO reduced DNA fragmentation and prevented caspase-3 activation, with upregulation of Bcl-XL and XIAP. The antiapoptotic effects of EPO were dependent on JAK2 signaling and the phosphorylation of Akt by phosphatidylinositol 3-kinase. These findings may have major implications in the treatment of acute renal tubular damage.
This article has been cited by other articles:
 |
|
 |
|
  A. C. Breggia, D. M. Wojchowski, and J. Himmelfarb JAK2/Y343/STAT5 signaling axis is required for erythropoietin-mediated protection against ischemic injury in primary renal tubular epithelial cells Am J Physiol Renal Physiol, December 1, 2008; 295(6): F1689 - F1695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Rosenberger, S. Rosen, A. Shina, U. Frei, K.-U. Eckardt, L. A. Flippin, M. Arend, S. J. Klaus, and S. N. Heyman Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney Nephrol. Dial. Transplant., November 1, 2008; 23(11): 3472 - 3478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Bi, J. Guo, A. Marlier, S. R. Lin, and L. G. Cantley Erythropoietin expands a stromal cell population that can mediate renoprotection Am J Physiol Renal Physiol, October 1, 2008; 295(4): F1017 - F1022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Sanz, B. Santamaria, M. Ruiz-Ortega, J. Egido, and A. Ortiz Mechanisms of Renal Apoptosis in Health and Disease J. Am. Soc. Nephrol., September 1, 2008; 19(9): 1634 - 1642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yokomaku, T. Sugimoto, S. Kume, S.-i. Araki, K. Isshiki, M. Chin-Kanasaki, M. Sakaguchi, N. Nitta, M. Haneda, D. Koya, et al. Asialoerythropoietin Prevents Contrast-Induced Nephropathy J. Am. Soc. Nephrol., February 1, 2008; 19(2): 321 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Schwenger, C. Morath, and M. Zeier Use of Erythropoietin after solid organ transplantation Nephrol. Dial. Transplant., September 1, 2007; 22(suppl_8): viii47 - viii49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mitra, S. Bansal, W. Wang, S. Falk, E. Zolty, and R. W. Schrier Erythropoietin ameliorates renal dysfunction during endotoxaemia Nephrol. Dial. Transplant., August 1, 2007; 22(8): 2349 - 2353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Menne, J.-K. Park, N. Shushakova, M. Mengel, M. Meier, and D. Fliser The Continuous Erythropoietin Receptor Activator Affects Different Pathways of Diabetic Renal Injury J. Am. Soc. Nephrol., July 1, 2007; 18(7): 2046 - 2053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Horl, Y. Vanrenterghem, P. Aljama, P. Brunet, R. Brunkhorst, L. Gesualdo, I. Macdougall, C. Wanner, and B. Wikstrom OPTA: Optimal treatment of anaemia in patients with chronic kidney disease (CKD) Nephrol. Dial. Transplant., June 1, 2007; 22(suppl_3): iii20 - iii26. [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Park, M.-J. Choi, I.-K. Song, S.-Y. Choi, J.-O. Nam, C.-D. Kim, B.-H. Lee, R.-W. Park, K. M. Park, Y.-J. Kim, et al. Erythropoietin Decreases Renal Fibrosis in Mice with Ureteral Obstruction: Role of Inhibiting TGF-beta-Induced Epithelial-to-Mesenchymal Transition J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1497 - 1507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kojima, T. Tanaka, R. Inagi, H. Kato, T. Yamashita, A. Sakiyama, O. Ohneda, N. Takeda, M. Sata, T. Miyata, et al. Protective Role of Hypoxia-Inducible Factor-2{alpha} against Ischemic Damage and Oxidative Stress in the Kidney J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1218 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Bernhardt, M. S. Wiesener, A. Weidemann, R. Schmitt, W. Weichert, P. Lechler, V. Campean, A. C. M. Ong, C. Willam, N. Gretz, et al. Involvement of Hypoxia-Inducible Transcription Factors in Polycystic Kidney Disease Am. J. Pathol., March 1, 2007; 170(3): 830 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Jo, M. H. Rosner, and M. D. Okusa Pharmacologic Treatment of Acute Kidney Injury: Why Drugs Haven't Worked and What Is on the Horizon Clin. J. Am. Soc. Nephrol., March 1, 2007; 2(2): 356 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Aydin, A. J. van Zonneveld, J. W. de Fijter, and T. J. Rabelink New horizons in prevention and treatment of ischaemic injury to kidney transplants Nephrol. Dial. Transplant., February 1, 2007; 22(2): 342 - 346. [Full Text] [PDF]
|
|
|
|
|
|
A. Grenz, T. Eckle, H. Zhang, D. Y. Huang, M. Wehrmann, C. Kohle, K. Unertl, H. Osswald, and H. K. Eltzschig Use of a hanging-weight system for isolated renal artery occlusion during ischemic preconditioning in mice Am J Physiol Renal Physiol, January 1, 2007; 292(1): F475 - F485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. P. Shaik, E. K. Fifer, and G. Nowak Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells Am J Physiol Renal Physiol, January 1, 2007; 292(1): F292 - F303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. B. Drueke, F. Locatelli, N. Clyne, K.-U. Eckardt, I. C. Macdougall, D. Tsakiris, H.-U. Burger, A. Scherhag, and the CREATE Investigators Normalization of Hemoglobin Level in Patients with Chronic Kidney Disease and Anemia N. Engl. J. Med., November 16, 2006; 355(20): 2071 - 2084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Jie, M. C. Verhaar, M.-J. M. Cramer, K. van der Putten, C. A. J. M. Gaillard, P. A. Doevendans, H. A. Koomans, J. A. Joles, and B. Braam Erythropoietin and the cardiorenal syndrome: cellular mechanisms on the cardiorenal connectors Am J Physiol Renal Physiol, November 1, 2006; 291(5): F932 - F944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Bernhardt, V. Campean, S. Kany, J.-S. Jurgensen, A. Weidemann, C. Warnecke, M. Arend, S. Klaus, V. Gunzler, K. Amann, et al. Preconditional Activation of Hypoxia-Inducible Factors Ameliorates Ischemic Acute Renal Failure J. Am. Soc. Nephrol., July 1, 2006; 17(7): 1970 - 1978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, M. P. Biju, M.-H. Wang, V. H. Haase, and Z. Dong Cytoprotective Effects of Hypoxia against Cisplatin-Induced Tubular Cell Apoptosis: Involvement of Mitochondrial Inhibition and p53 Suppression J. Am. Soc. Nephrol., July 1, 2006; 17(7): 1875 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Spandou, I. Tsouchnikas, G. Karkavelas, E. Dounousi, C. Simeonidou, O. Guiba-Tziampiri, and D. Tsakiris Erythropoietin attenuates renal injury in experimental acute renal failure ischaemic/reperfusion model Nephrol. Dial. Transplant., February 1, 2006; 21(2): 330 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Wei, X.-M. Yin, M.-H. Wang, and Z. Dong Bid deficiency ameliorates ischemic renal failure and delays animal death in C57BL/6 mice Am J Physiol Renal Physiol, January 1, 2006; 290(1): F35 - F42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tanaka, I. Kojima, T. Ohse, R. Inagi, T. Miyata, J. R. Ingelfinger, T. Fujita, and M. Nangaku Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1123 - F1133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Brooks, P. Ketsawatsomkron, Y. Sui, J. Wang, C.-Y. Wang, F.-S. Yu, and Z. Dong Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome Am J Physiol Renal Physiol, August 1, 2005; 289(2): F410 - F419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rossert and K.-U. Eckardt Erythropoietin receptors: their role beyond erythropoiesis Nephrol. Dial. Transplant., June 1, 2005; 20(6): 1025 - 1028. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rui, Q. Feng, M. Lei, T. Peng, J. Zhang, M. Xu, E. Dale Abel, A. Xenocostas, and P. R. Kvietys Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1 Cardiovasc Res, February 15, 2005; 65(3): 719 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pfeilschifter and A. Huwiler Erythropoietin Is More than Just a Promoter of Erythropoiesis J. Am. Soc. Nephrol., August 1, 2004; 15(8): 2240 - 2241. [Full Text] [PDF]
|
|
|
HOME
CURRENT ISSUE
ARCHIVES
JASN Express
ONLINE SUBMISSION
AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP |
Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673
