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Published ahead of print on November 9, 2005
J Am Soc Nephrol 16: 3477-3484, 2005
© 2005 American Society of Nephrology
doi: 10.1681/ASN.2005080806
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Reviews

Observational Research Databases in Renal Disease

Michael Shlipak* and Catherine Stehman-Breen{dagger}

* General Internal Medicine Section, Veterans Affairs Medical Center, and Departments of Medicine, Epidemiology, and Biostatistics, University of California, San Francisco, San Francisco, California; and {dagger} Amgen Inc., Thousand Oaks, California, and Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington

Address correspondence to: Dr. Catherine Stehman-Breen, Amgen Inc., One Amgen Center Drive, MS 38-3-C, Thousand Oaks, CA 91362. Phone: 805-447-7791; Fax: 805-498-0946; E-mail: cstehman{at}amgen.com

Observational, patient-oriented research is a term that describes clinical or community-based studies in that they do not involve an experiment or intervention. Observational research studies can be designed and implemented by a primary data collection or using previously collected patient data. The latter is less expensive, although it has some distinct limitations. Many research databases are readily available and can be used to answer important questions that are relevant to kidney disease. This review summarizes the types of research analyses that can be conducted using existing databases, the types of research databases available, and a general approach for addressing a proposed research question using existing data.




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