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Published ahead of print on January 12, 2005
J Am Soc Nephrol 16: 305-312, 2005
© 2005 American Society of Nephrology
doi: 10.1681/ASN.2004080645
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Frontiers in Nephrology

Caenorhabditis elegans as a Model to Study Renal Development and Disease: Sexy Cilia

Maureen M. Barr

School of Pharmacy, University of Wisconsin Madison, Madison, Wisconsin

Address correspondence to: Dr. Maureen M. Barr, School of Pharmacy, University of Wisconsin at Madison, 777 Highland Avenue, Madison, WI 53705. Phone: 608-265-1174; Fax: 608-262-5345; E-mail: mmbarr{at}pharmacy.wisc.edu

The nematode Caenorhabditis elegans has no kidney per se, yet "the worm" has proved to be an excellent model to study renal-related issues, including tubulogenesis of the excretory canal, membrane transport and ion channel function, and human genetic diseases including autosomal dominant polycystic kidney disease (ADPKD). The goal of this review is to explain how C. elegans has provided insight into cilia development, cilia function, and human cystic kidney diseases.




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