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Renin Inhibition: What Are the Therapeutic Opportunities?

Departments of Medicine and Radiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts

Address correspondence to: Dr. Norman K. Hollenberg, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115. Phone: 617-732-6682; Fax: 617-232-2869; E-mail: djpagecapo{at}rics.bwh.harvard.edu

Abstract

Blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers has become a crucial element in cardiovascular and renal medicine. This review evaluates the potential of renin inhibition as an adjunct to therapies that depend on renin system interruption.

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