2007 JASN IMPACT FACTOR 7.111	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) All Versions of this Article: ASN.2004030208v1 16/3/791    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Domrongkitchaiporn, S. Articles by Yipintsoi, T. Search for Related Content PubMed PubMed Citation Articles by Domrongkitchaiporn, S. Articles by Yipintsoi, T.

Risk Factors for Development of Decreased Kidney Function in a Southeast Asian Population: A 12-Year Cohort Study

Somnuek Domrongkitchaiporn^*, Piyamitr Sritara^*, Chagriya Kitiyakara^*, Wasana Stitchantrakul, Vorasakdi Krittaphol, Porntip Lolekha, Sayan Cheepudomwit^* and Tada Yipintsoi^*

^* Department of Medicine, Department of Pathology, and Research Center, Ramathibodi Hospital, Mahidol University, Bangkok; and Electricity Generating Authority of Thailand, Bangkok, Thailand

Address correspondence to: Dr. Somnuek Domrongkitchaiporn, Department of Medicine, Ramathibodi Hospital, Rama 6 Road, Bangkok 10400, Thailand. Phone: 662-201-1116; Fax: 662-246-2123; E-mail: rasdr{at}mahidol.ac.th

End-stage kidney disease has become an increasing burden in all regions of the world. However, limited epidemiologic data on chronic kidney disease in Southeast Asian populations are available. Therefore, a cohort study over a period of 12 yr (1985 to 1997) in 3499 employees of the Electric Generation Authority of Thailand, aged 35 to 55 yr, was conducted to determine the prevalence of decreased kidney function and risk factors associated with future development of decreased kidney function. The prevalence of decreased kidney function (GFR <60 ml/min) increased from 1.7% (95% confidence interval [CI], 1.3 to 2.1) in 1985 to 6.8% (95% CI, 5.7 to 7.9) in 1997, and the prevalence of elevated serum creatinine was 6.1% (95% CI, 5.3 to 6.9) and 16.9% (95% CI, 15.3 to 18.5) in 1985 and 1997 surveys, respectively. The adjusted odds ratio for future development of decreased kidney function was 2.57 (1.0 to 6.81) for systolic hypertension (>159 mmHg), 1.82 (1.12 to 2.98) for hyperuricemia (>6.29 mg/dl), 1.68 (1.02 to 2.77) for elevated body mass index (>24.9 kg/m²) compared with subjects with systolic BP <140 mmHg, serum uric acid <4.5 mg/dl, and body mass index 20.8 to 22.8 kg/m². The rising prevalence of decreased kidney function in this population resulted mainly from the increasing prevalence of the risk factors in the population. Screening to detect decreased kidney function and early intervention to modify the associated risk factors should be considered in otherwise healthy individuals. Future studies are also necessary to determine whether implementation of these measures results in a reduction of ESRD incidence in the population.

This article has been cited by other articles:

				R. P. Obermayr, C. Temml, G. Gutjahr, M. Knechtelsdorfer, R. Oberbauer, and R. Klauser-Braun Elevated Uric Acid Increases the Risk for Kidney Disease J. Am. Soc. Nephrol., December 1, 2008; 19(12): 2407 - 2413. [Abstract] [Full Text] [PDF]

				R. P. Obermayr, C. Temml, M. Knechtelsdorfer, G. Gutjahr, J. Kletzmayr, S. Heiss, A. Ponholzer, S. Madersbacher, R. Oberbauer, and R. Klauser-Braun Predictors of new-onset decline in kidney function in a general middle-european population Nephrol. Dial. Transplant., April 1, 2008; 23(4): 1265 - 1273. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673