Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on March 2, 2005
J Am Soc Nephrol 16: 1085-1090, 2005
© 2005 American Society of Nephrology
doi: 10.1681/ASN.2004100817
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
ASN.2004100817v1
16/4/1085    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, Y.
Right arrow Articles by Freedman, B. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, Y.
Right arrow Articles by Freedman, B. I.

Human Genetics

T-786C Polymorphism of the Endothelial Nitric Oxide Synthase Gene Is Associated with Albuminuria in the Diabetes Heart Study

Yongmei Liu*, Kathryn P. Burdon{dagger}, Carl D. Langefeld*, Stephanie R. Beck*, Lynne E. Wagenknecht*, Stephen S. Rich*, Donald W. Bowden{dagger},{ddagger} and Barry I. Freedman{ddagger}

* Departments of Public Health Sciences, {dagger} Biochemistry/Human Genome Center, and {ddagger} Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Address correspondence to: Dr. Yongmei Liu, Wake Forest University School of Medicine, Department of Public Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157. Phone: 336-716-9503; Fax: 336-716-6427; E-mail: yoliu{at}wfubmc.edu

Received for publication October 1, 2004. Accepted for publication January 21, 2005.

Albuminuria demonstrates significant heritability in multiply affected hypertensive and diabetic families. The role of endothelial nitric oxide synthase (eNOS) gene variants as risk factors for albuminuria was investigated in 590 European American siblings from 230 families in the Diabetes Heart Study. Two polymorphisms in the eNOS gene (T-786C in the promoter region and Glu298Asp in exon 7) were genotyped. Albuminuria was defined as an albumin:creatinine ratio (ACR) ≥17 mg/g in men and ≥25 mg/g in women. Tests of association were based on generalized estimating equations, and tests of linkage disequilibrium were based on the quantitative pedigree disequilibrium test. A total of 83% of participants had type 2 diabetes. The median ACR was 10.7 mg/g (interquartile range, 5.1 to 32.8), and 34% (202 of 590) of participants had an elevated ACR. The eNOS –786C allele but not the Glu298Asp was associated with increased ACR (31% increase in absolute level of ACR for each additional copy of the –786C allele; P < 0.0001) and a higher risk for albuminuria (odds ratio, 1.55 for each additional copy of the –786C allele; P = 0.0005). Adjustment for the nongenetic determinants of ACR had no significant effect on the results; neither did stratification by gender, presence of diabetes, and the Glu298Asp genotype. Results were confirmed by quantitative pedigree disequilibrium test analysis and were consistent with haplotype analysis. The –786C eNOS variant was positively correlated with a higher prevalence and a greater degree of albuminuria in European American families in both diabetic and nondiabetic family members.




This article has been cited by other articles:


Home page
 DiabetesHome page
J. R. Schelling, H. E. Abboud, S. B. Nicholas, M. V. Pahl, J. R. Sedor, S. G. Adler, N. H. Arar, D. W. Bowden, R. C. Elston, B. I. Freedman, et al.
Genome-Wide Scan for Estimated Glomerular Filtration Rate in Multi-Ethnic Diabetic Populations: The Family Investigation of Nephropathy and Diabetes (FIND)
Diabetes, January 1, 2008; 57(1): 235 - 243.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
B. I. Freedman, M. Bostrom, P. Daeihagh, and D. W. Bowden
Genetic Factors in Diabetic Nephropathy
Clin. J. Am. Soc. Nephrol., November 1, 2007; 2(6): 1306 - 1316.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Kanetsuna, K. Takahashi, M. Nagata, M. A. Gannon, M. D. Breyer, R. C. Harris, and T. Takahashi
Deficiency of Endothelial Nitric-Oxide Synthase Confers Susceptibility to Diabetic Nephropathy in Nephropathy-Resistant Inbred Mice
Am. J. Pathol., May 1, 2007; 170(5): 1473 - 1484.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
I. Zineh, A. L. Beitelshees, and M. J. Haller
NOS3 Polymorphisms Are Associated With Arterial Stiffness in Children With Type 1 Diabetes
Diabetes Care, March 1, 2007; 30(3): 689 - 693.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
B. I. Freedman, D. W. Bowden, M. M. Sale, C. D. Langefeld, and S. S. Rich
Genetic Susceptibility Contributes to Renal and Cardiovascular Complications of Type 2 Diabetes Mellitus
Hypertension, July 1, 2006; 48(1): 8 - 13.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. M. Sale and B. I. Freedman
Genetic determinants of albuminuria and renal disease in diabetes mellitus
Nephrol. Dial. Transplant., January 1, 2006; 21(1): 13 - 16.
[Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673