Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on May 11, 2005
J Am Soc Nephrol 16: 1920-1928, 2005
© 2005 American Society of Nephrology
doi: 10.1681/ASN.2004121079
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
ASN.2004121079v1
16/7/1920    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bankir, L.
Right arrow Articles by Bichet, D. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bankir, L.
Right arrow Articles by Bichet, D. G.

Cell and Transport Physiology

Vasopressin-V2 Receptor Stimulation Reduces Sodium Excretion in Healthy Humans

Lise Bankir*, Sandrine Fernandes*, Pascale Bardoux*, Nadine Bouby* and Daniel G. Bichet{dagger}

* INSERM Unité 367, Institut du Fer à Moulin, Paris, France; and {dagger} Service de Néphrologie, Hôpital du Sacré-Coeur, Département de Médecine, Université de Montréal, Montréal, Québec, Canada

Address correspondence to: Dr. Lise Bankir, INSERM Unité 367, Institut du Fer à Moulin, 17 Rue du Fer à Moulin, 75005 Paris, France. Phone: 33-1-45-87-6121; Fax: 33-1-45-35-6629; bankir{at}fer-a-moulin.inserm.fr

Received for publication December 13, 2004. Accepted for publication March 17, 2005.

In addition to its effect on water permeability, vasopressin, through its V2 receptors (AVPR2), stimulates Na reabsorption in the collecting duct by increasing the activity of the amiloride-sensitive sodium channel ENaC. This study evaluated whether dDAVP (a potent AVPR2 agonist) reduces sodium excretion in healthy humans (n = 6) and in patients with central (C; n = 2) or nephrogenic (N) diabetes insipidus (DI) as a result of mutations of either the aquaporin 2 gene (AQP2; n = 3) or AVPR2 (n = 10). dDAVP was infused intravenously (0.3 µg/kg body wt in 20 min), and urine was collected for 60 min before (basal) and 150 min after the infusion. dDAVP markedly reduced both urine flow rate and sodium excretion in healthy individuals. A reduction in sodium excretion was also observed in CDI and NDI-AQP2 patients but not in NDI-AVPR2 patients. The magnitude of the fall in sodium excretion correlated with the rise in urine osmolality and the fall in urine output but not with the simultaneously observed fall in mean BP. These results suggest that the dDAVP-induced antinatriuresis is due to a direct V2 receptor–dependent stimulation of sodium reabsorption in the collecting duct and is not secondary to a hemodynamic effect. In conclusion, this study reveals a potent V2-dependent antinatriuretic effect of vasopressin in humans. The possibility that an inappropriate stimulation of ENaC by vasopressin might lead to significant sodium retention in chronic situations remains to be determined.




This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
J. Perucca, D. G. Bichet, P. Bardoux, N. Bouby, and L. Bankir
Sodium Excretion in Response to Vasopressin and Selective Vasopressin Receptor Antagonists
J. Am. Soc. Nephrol., September 1, 2008; 19(9): 1721 - 1731.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. Bankir, M. Bochud, M. Maillard, P. Bovet, A. Gabriel, and M. Burnier
Nighttime Blood Pressure and Nocturnal Dipping Are Associated With Daytime Urinary Sodium Excretion in African Subjects
Hypertension, April 1, 2008; 51(4): 891 - 898.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Gutkowska, M. Miszkurka, B. Danalache, N. Gassanov, D. Wang, and M. Jankowski
Functional arginine vasopressin system in early heart maturation
Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2262 - H2270.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
L. Bankir, J. Perucca, and M. H. Weinberger
Ethnic Differences in Urine Concentration: Possible Relationship to Blood Pressure
Clin. J. Am. Soc. Nephrol., March 1, 2007; 2(2): 304 - 312.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
F. C. Luft
Vasopressin, Urine Concentration, and Hypertension: A New Perspective on an Old Story
Clin. J. Am. Soc. Nephrol., March 1, 2007; 2(2): 196 - 197.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Perucca, N. Bouby, P. Valeix, and L. Bankir
Sex difference in urine concentration across differing ages, sodium intake, and level of kidney disease
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R700 - R705.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Carmosino, H. L. Brooks, Q. Cai, L. S. Davis, S. Opalenik, C. Hao, and M. D. Breyer
Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct
Am J Physiol Renal Physiol, January 1, 2007; 292(1): F351 - F360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. H. Robben, N. V. A. M. Knoers, and P. M. T. Deen
Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus.
Am J Physiol Renal Physiol, August 1, 2006; 291(2): F257 - F270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. de Seigneux, S. W. Kim, S. C. Hemmingsen, J. Frokiaer, and S. Nielsen
Increased expression but not targeting of ENaC in adrenalectomized rats with PAN-induced nephrotic syndrome
Am J Physiol Renal Physiol, July 1, 2006; 291(1): F208 - F217.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Q. Cai, M. Keck, M. R. McReynolds, J. D. Klein, K. Greer, K. Sharma, J. B. Hoying, J. M. Sands, and H. L. Brooks
Effects of water restriction on gene expression in mouse renal medulla: identification of 3betaHSD4 as a collecting duct protein
Am J Physiol Renal Physiol, July 1, 2006; 291(1): F218 - F224.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L.-M. Yang, R. Rinke, and C. Korbmacher
Stimulation of the Epithelial Sodium Channel (ENaC) by cAMP Involves Putative ERK Phosphorylation Sites in the C Termini of the Channel's beta- and {gamma}-Subunit
J. Biol. Chem., April 14, 2006; 281(15): 9859 - 9868.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
V. Bernier, J.-P. Morello, A. Zarruk, N. Debrand, A. Salahpour, M. Lonergan, M.-F. Arthus, A. Laperriere, R. Brouard, M. Bouvier, et al.
Pharmacologic Chaperones as a Potential Treatment for X-Linked Nephrogenic Diabetes Insipidus
J. Am. Soc. Nephrol., January 1, 2006; 17(1): 232 - 243.
[Abstract] [Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673