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Adverse Perinatal Outcome and Later Kidney Biopsy in the Mother

Bjørn Egil Vikse^*,,, Lorentz M. Irgens^,, Leif Bostad^,|| and Bjarne M. Iversen^*,,

^* Renal Research Group, Institute of Medicine, University of Bergen, Bergen; The Norwegian Kidney Biopsy Registry, Department of Medicine, and ^|| The Norwegian Kidney Biopsy Registry, Department of Pathology, Haukeland University Hospital, Bergen; Locus for Registry Based Epidemiology, University of Bergen, Bergen; and The Medical Birth Registry of Norway, University of Bergen and Norwegian Institute of Public Health, Bergen, Norway

Address correspondence to: Dr. Bjørn Egil Vikse, Department of Cardiology, Haukeland University Hospital, 5021 Bergen, Norway. Phone: +47-9925-0064; Fax: +47-5597-5890; E-mail: bjorn.vikse{at}med.uib.no

Received for publication May 12, 2005. Accepted for publication November 23, 2005.

Strong associations of adverse perinatal outcomes have been identified with later cardiovascular disease in the mother. Few studies have addressed associations with kidney disease. This study investigated whether perinatal outcomes are associated with later clinical kidney disease as diagnosed by kidney biopsy. The Medical Birth Registry of Norway contains data on all childbirths in Norway since 1967. The Norwegian Kidney Biopsy Registry contains data on all kidney biopsies in Norway since 1988. All women with a first singleton delivery from 1967 to 1998 were included. Pregnancy-related predictors of later kidney biopsy were analyzed by Cox regression analyses. A total of 756,420 women were included, and after a mean period of 15.9 ± 9.4 yr, 588 had a kidney biopsy. Compared with women without preeclampsia and with offspring with birth weight of 2.5 kg, women with no preeclampsia and with offspring with birth weight of 1.5 to 2.5 kg had a relative risk (RR) for a later kidney biopsy of 1.7, women with no preeclampsia and with offspring with birth weight of <1.5 kg had an RR of 2.9, women with preeclampsia and with offspring with a birth weight of 2.5 kg had an RR of 2.5, women with preeclampsia and with offspring with a birth weight of 1.5 to 2.5 kg had an RR of 4.5, and women with preeclampsia and with offspring with a birth weight of <1.5 kg had an RR of 17. Similar results were found in adjusted analyses and after exclusion of women with diabetes, kidney disease, or rheumatic disease before pregnancy. The same risk patterns applied to any of the specific categories of kidney disease as well as specific kidney diseases investigated. Women who have preeclampsia and give birth to offspring with low birth weight and short gestation have a substantially increased risk for having a later kidney biopsy.

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