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Anti-Neutrophil Cytoplasm-Associated Glomerulonephritis

Division of Immunity and Infection, The Medical School, University of Birmingham, Birmingham, United Kingdom

Address correspondence to: Prof. Caroline Savage, Division of Immunity and Infection, The Medical School, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, United Kingdom. Phone: +21-414-6841; Fax: +21-414-6794; E-mail: c.o.s.savage{at}bham.ac.uk

Wegener’s granulomatosis, microscopic polyangiitis, and renal limited vasculitis are associated with circulating anti-neutrophil cytoplasm antibodies and are an important cause of rapidly progressive glomerulonephritis. This review gives an account of recent advances in the understanding of the pathogenesis underlying these conditions and how these may lead to future treatments. Consideration is given to recent clinical trials in the management of anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitides.

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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673