Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on July 26, 2006
J Am Soc Nephrol 17: 2390-2401, 2006
© 2006 American Society of Nephrology
doi: 10.1681/ASN.2006030218
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
ASN.2006030218v1
17/9/2390    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Little, M. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Little, M. H.

Reviews

Regrow or Repair: Potential Regenerative Therapies for the Kidney

Melissa H. Little

Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland, Australia

Address correspondence to: Prof. Melissa H. Little, Institute for Molecular Bioscience, Queensland Bioscience Precinct, University of Queensland, St. Lucia, Brisbane, Qld, 4072, Australia. Phone: +61-7-3346-2054; Fax: +61-7-3346-2101; m.little{at}imb.uq.edu.au; Web: www.imb.uq.edu.au

Regenerative medicine is being heralded in a similar way as gene therapy was some 15 yr ago. It is an area of intense excitement and potential, as well as myth and disinformation. However, with the increasing rate of end-stage renal failure and limited alternatives for its treatment, we must begin to investigate seriously potential regenerative approaches for the kidney. This review defines which regenerative options there might be for renal disease, summarizes the progress that has been made to date, and investigates some of the unique obstacles to such treatments that the kidney presents. The options discussed include in situ organ repair via bone marrow recruitment or dedifferentiation; ex vivo stem cell therapies, including both autologous and nonautologous options; and bioengineering approaches for the creation of a replacement organ.




This article has been cited by other articles:


Home page
 JEMHome page
B. Mazzinghi, E. Ronconi, E. Lazzeri, C. Sagrinati, L. Ballerini, M. L. Angelotti, E. Parente, R. Mancina, G. S. Netti, F. Becherucci, et al.
Essential but differential role for CXCR4 and CXCR7 in the therapeutic homingof human renal progenitor cells
J. Exp. Med., February 18, 2008; 205(2): 479 - 490.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
P. Boor, K. Sebekova, T. Ostendorf, and J. Floege
Treatment targets in renal fibrosis
Nephrol. Dial. Transplant., December 1, 2007; 22(12): 3391 - 3407.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
E. Lazzeri, C. Crescioli, E. Ronconi, B. Mazzinghi, C. Sagrinati, G. S. Netti, M. L. Angelotti, E. Parente, L. Ballerini, L. Cosmi, et al.
Regenerative Potential of Embryonic Renal Multipotent Progenitors in Acute Renal Failure
J. Am. Soc. Nephrol., December 1, 2007; 18(12): 3128 - 3138.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
J. Li, J. A. Deane, N. V. Campanale, J. F. Bertram, and S. D. Ricardo
The Contribution of Bone Marrow-Derived Cells to the Development of Renal Interstitial Fibrosis
Stem Cells, March 1, 2007; 25(3): 697 - 706.
[Abstract] [Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673