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Published ahead of print on September 5, 2007
J Am Soc Nephrol 18: 2628-2635, 2007
© 2007 American Society of Nephrology
doi: 10.1681/ASN.2007030273
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Brief Reviews

Dendritic Cells in the Kidney

Rohan John{dagger} and Peter J. Nelson{dagger}

{dagger} Division of Nephrology, New York University School of Medicine, New York, New York

Correspondence: Dr. Peter J. Nelson, Division of Nephrology, New York University School of Medicine, Smilow Research Center, 522 First Avenue, New York, NY 10016. Phone: 212-263-7681; Fax: 212-263-7683; E-mail: nelsop02{at}popmail.med.nyu.edu

Dendritic cells (DC) in nonlymphoid organs function at the crossroads of innate and adaptive immunity, self-tolerance, and tissue homeostasis. This review provides an overview of the study of DC in the kidney, tracing its history leading to the current knowledge of the origins, migration, and function of renal DC. Together, these studies suggest that renal DC play a critical role in the health and disease of the kidney, opening the way to direct targeting of renal DC for therapeutic benefit.




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