Journal of the American Society of Nephrology
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CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on October 17, 2007
J Am Soc Nephrol 18: 2853-2862, 2007
© 2007 American Society of Nephrology
doi: 10.1681/ASN.2007040514
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Special Articles

Frontiers in Nephrology: Genomic Approaches to Understanding the Molecular Basis of Atherosclerosis

Euan A. Ashley, Joshua M. Spin, Raymond Tabibiazar and Thomas Quertermous

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California

Correspondence: Dr. Thomas Quertermous, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Falk CVRC, Stanford, CA 94305. Phone: 650-723-5013; Fax: 650-725-2178; E-mail: tomq1{at}stanford.edu

Atherosclerosis is a complex multicellular disease that is responsible for pathology in various organ systems. The understanding of its initiation and progression has been enhanced in recent years by the application of high-throughput genomic tools such as the microarray. Increasing in genomic coverage, such tools allow a view of the disease unaffected by previous conjecture as to the primary signal of interest. New statistical tools and pathway modeling techniques have established definitively for the first time the central role of inflammation in this process. This article reviews the genomic literature relating to atherosclerosis from cell culture, animal models, and human tissues. In this comparison of these differing approaches, the available data are synthesized to reach a new understanding of the complex interplay between vascular wall and immune system components.






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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673