2008 JASN IMPACT FACTOR 7.505	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text Full Text (PDF) All Versions of this Article: ASN.2006090956v1 18/4/1057    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fliser, D. Articles by Mischak, H. Search for Related Content PubMed PubMed Citation Articles by Fliser, D. Articles by Mischak, H.

Advances in Urinary Proteome Analysis and Biomarker Discovery

Danilo Fliser^*, Jan Novak, Visith Thongboonkerd, Àngel Argilés, Vera Jankowski^||, Mark A. Girolami^¶, Joachim Jankowski^|| and Harald Mischak^**

^* Medical School Hannover, Hannover, Germany; University of Alabama at Birmingham, Birmingham, Alabama; Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Nephrology, University Hospital, Néphrologie et Dialyse St Guilhem and SAS RD, Néphrologie, Montpellier, France; ^|| Nephrology Department, Charité Hospital, Berlin, Germany; ^¶ Department of Computing Science, University of Glasgow, Glasgow, Scotland; and ^** Mosaiques-Diagnostics and Therapeutics AG, Hannover, Germany

Address correspondence to: Dr. Harald Mischak, Mosaiques Diagnostics & Therapeutics AG, Mellendorfer Strasse 7-9, D-30625 Hannover, Germany. Phone: +49-511-554744-13; Fax: +49-511-554744-31; E-mail: mischak{at}mosaiques-diagnostics.com

Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still challenges in clinical nephrology. Definition of biomarkers on the basis of proteome analysis, especially of the urine, has advanced recently and may provide new tools to solve those challenges. This article highlights the most promising technological approaches toward deciphering the human proteome and applications of the knowledge in clinical nephrology, with emphasis on the urinary proteome. The data in the current literature indicate that although a thorough investigation of the entire urinary proteome is still a distant goal, clinical applications are already available. Progress in the analysis of human proteome in health and disease will depend more on the standardization of data and availability of suitable bioinformatics and software solutions than on new technological advances. It is predicted that proteomics will play an important role in clinical nephrology in the very near future and that this progress will require interactive dialogue and collaboration between clinicians and analytical specialists.

This article has been cited by other articles:

				J Vlaanderen, L E Moore, M T Smith, Q Lan, L Zhang, C F Skibola, N Rothman, and R Vermeulen Application of OMICS technologies in occupational and environmental health research; current status and projections Occup. Environ. Med., February 1, 2010; 67(2): 136 - 143. [Abstract] [Full Text] [PDF]

				V. Thongboonkerd Current status of renal and urinary proteomics: ready for routine clinical application? Nephrol. Dial. Transplant., January 1, 2010; 25(1): 11 - 16. [Full Text] [PDF]

				M. Haubitz, D. M. Good, A. Woywodt, H. Haller, H. Rupprecht, D. Theodorescu, M. Dakna, J. J. Coon, and H. Mischak Identification and Validation of Urinary Biomarkers for Differential Diagnosis and Evaluation of Therapeutic Intervention in Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis Mol. Cell. Proteomics, October 1, 2009; 8(10): 2296 - 2307. [Abstract] [Full Text] [PDF]

				D. M. Schlatzer, J.-E. Dazard, M. Dharsee, R. M. Ewing, S. Ilchenko, I. Stewart, G. Christ, and M. R. Chance Urinary Protein Profiles in a Rat Model for Diabetic Complications Mol. Cell. Proteomics, September 1, 2009; 8(9): 2145 - 2158. [Abstract] [Full Text] [PDF]

				K. Bramham, H.D. Mistry, L. Poston, L.C. Chappell, and A.J. Thompson The non-invasive biopsy--will urinary proteomics make the renal tissue biopsy redundant? QJM, August 1, 2009; 102(8): 523 - 538. [Abstract] [Full Text] [PDF]

				P. Saetun, T. Semangoen, and V. Thongboonkerd Characterizations of urinary sediments precipitated after freezing and their effects on urinary protein and chemical analyses Am J Physiol Renal Physiol, June 1, 2009; 296(6): F1346 - F1354. [Abstract] [Full Text] [PDF]

				S. Decramer, A. G. de Peredo, B. Breuil, H. Mischak, B. Monsarrat, J.-L. Bascands, and J. P. Schanstra Urine in Clinical Proteomics Mol. Cell. Proteomics, October 1, 2008; 7(10): 1850 - 1862. [Abstract] [Full Text] [PDF]

				R. Raaijmakers, W. Pluk, C. H. Schroder, J. Gloerich, E. A.M. Cornelissen, H. J.C.T. Wessels, J. L. Willems, L. A.H. Monnens, and L. P.W.J. van den Heuvel Proteomic profiling and identification in peritoneal fluid of children treated by peritoneal dialysis Nephrol. Dial. Transplant., July 1, 2008; 23(7): 2402 - 2405. [Abstract] [Full Text] [PDF]

				K. Rossing, H. Mischak, M. Dakna, P. Zurbig, J. Novak, B. A. Julian, D. M. Good, J. J. Coon, L. Tarnow, P. Rossing, et al. Urinary Proteomics in Diabetes and CKD J. Am. Soc. Nephrol., July 1, 2008; 19(7): 1283 - 1290. [Abstract] [Full Text] [PDF]

				P. Stenvinkel, J. J. Carrero, J. Axelsson, B. Lindholm, O. Heimburger, and Z. Massy Emerging Biomarkers for Evaluating Cardiovascular Risk in the Chronic Kidney Disease Patient: How Do New Pieces Fit into the Uremic Puzzle? Clin. J. Am. Soc. Nephrol., March 1, 2008; 3(2): 505 - 521. [Abstract] [Full Text] [PDF]

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673