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Published ahead of print on June 13, 2007
J Am Soc Nephrol 18: 1999-2003, 2007
© 2007 American Society of Nephrology
doi: 10.1681/ASN.2007020143
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Clinical Commentary

Hypophosphatemia: Clinical Consequences and Management

Steven M. Brunelli*,{dagger} and Stanley Goldfarb*

* Renal-Electrolyte and Hypertension Division, Department of Medicine, and {dagger} Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Correspondence: Dr Steven Brunelli, 423 Guardian Drive, Blackley Hall, Suite 109, Philadelphia, PA 19104. Phone: 215-662-2638; Fax: 215-898-0643; E-mail: steven.brunelli{at}uphs.upenn.edu

Current evidence regarding the clinical consequences of hypophosphatemia is not straightforward. Given the potentially different implications of hypophosphatemia among various patient groups, this commentary touches on patients with low serum phosphate after acute hospitalization, those with chronic ambulatory hypophosphatemia, and those with hypophosphatemia in the setting of advanced renal disease. Finally, this commentary examines the evidence regarding how best to replete phosphorous in the hypophosphatemic patient.




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