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Published ahead of print on June 13, 2007
J Am Soc Nephrol 18: 2028-2031, 2007
© 2007 American Society of Nephrology
doi: 10.1681/ASN.2006111302
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Science in Renal Medicine

Decreased Effective Blood Volume in Edematous Disorders: What Does This Mean?

Robert W. Schrier

University of Colorado School of Medicine, Denver, Colorado

Correspondence: Dr Robert W. Schrier, University of Colorado School of Medicine, 4200 E. Ninth Ave., B173, Denver, CO 80262. Phone: 303-315-8059; Fax: 303-315-2685; E-mail: robert.schrier{at}uchsc.edu

Edematous patients with renal sodium and water retention, particularly cardiac failure and cirrhosis, have been suggested to have a decreased "effective blood volume." This enigmatic and undefined term was coined because edematous patients were found to have increased, rather than the earlier proposed decreased, blood volumes. This article discusses the advances that have occurred in understanding the pathophysiology of edema as occurs in conditions such as cardiac failure, cirrhosis, and pregnancy. The regulatory mechanisms that lead to increased sodium and water retention by the normal kidney are related to arterial underfilling, as a result of a decrease in cardiac output, arterial vasodilation, or both.




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R. W. Schrier and S. Bansal
Pulmonary Hypertension, Right Ventricular Failure, and Kidney: Different from Left Ventricular Failure?
Clin. J. Am. Soc. Nephrol., September 1, 2008; 3(5): 1232 - 1237.
[Abstract] [Full Text] [PDF]


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