Journal of the American Society of Nephrology
2008 JASN IMPACT FACTOR 7.505 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on March 5, 2008
J Am Soc Nephrol 19: 2272-2275, 2008
© 2008 American Society of Nephrology
doi: 10.1681/ASN.2007121326
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
ASN.2007121326v1
19/12/2272    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thomson, S. C.
Right arrow Articles by Blantz, R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thomson, S. C.
Right arrow Articles by Blantz, R. C.

Science in Renal Medicine

Glomerulotubular Balance, Tubuloglomerular Feedback, and Salt Homeostasis

Scott C. Thomson and Roland C. Blantz

Department of Medicine, Division of Nephrology-Hypertension, University of California San Diego, and VA San Diego Healthcare System, San Diego, California

Correspondence: Dr. Scott C. Thomson, Department of Medicine, University of California, and VA San Diego Healthcare System, 3350 La Jolla Village Drive 9111H, San Diego, CA 92161. Phone: 858-552-7528; Fax: 858-552-7549; E-mail: rblantz{at}ucsd.edu

The homeostasis of NaCl is critical to complex organisms with closed blood systems. Kidneys regulate this salt excretion by modulating the rapport between glomeruli and tubules. The tubules respond to glomeruli with glomerulotubular balance, whereas glomeruli respond to tubules through tubuloglomerular feedback. These relationships are dynamic, mysterious, and amenable to mathematical analyses. The biology underlining what is known about these interactions is observational, fragmentary, and somewhat inconclusive. Discussed here is a simple tethering of these interrelated concepts.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Deng and S. C. Thomson
Renal NMDA receptors independently stimulate proximal reabsorption and glomerular filtration
Am J Physiol Renal Physiol, May 1, 2009; 296(5): F976 - F982.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. Singh, A. Deng, R. C. Blantz, and S. C. Thomson
Unexpected effect of angiotensin AT1 receptor blockade on tubuloglomerular feedback in early subtotal nephrectomy
Am J Physiol Renal Physiol, May 1, 2009; 296(5): F1158 - F1165.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. Bie, S. Molstrom, and S. Wamberg
Normotensive sodium loading in conscious dogs: regulation of renin secretion during {beta}-receptor blockade
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R428 - R435.
[Abstract] [Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673