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Published ahead of print on November 21, 2007
J Am Soc Nephrol 19: 260-268, 2008
© 2008 American Society of Nephrology
doi: 10.1681/ASN.2007050588
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BASIC RESEARCH

The Glomerular Transcriptome and a Predicted Protein–Protein Interaction Network

Liqun He*, Ying Sun*, Minoru Takemoto*, Jenny Norlin*, Karl Tryggvason*, Tore Samuelsson{dagger} and Christer Betsholtz*,{ddagger}

* Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, and {ddagger} Department of Medicine, Karolinska Institutet, Stockholm, and {dagger} Department of Medical Biochemistry, Göteborg University, Göteborg, Sweden

Correspondence: Dr. Christer Betsholtz, Department of Medicine, Karolinska Institutet, SE 171 77, Stockholm, Sweden. Phone: +46-8-52487960; Fax: +46-8-313445; E-mail: christer.betsholtz{at}ki.se

Received for publication May 21, 2007. Accepted for publication August 15, 2007.

To increase our understanding of the molecular composition of the kidney glomerulus, we performed a meta-analysis of available glomerular transcriptional profiles made from mouse and man using five different methodologies. We generated a combined catalogue of glomerulus-enriched genes that emerged from these different sources and then used this to construct a predicted protein–protein interaction network in the glomerulus (GlomNet). The combined glomerulus-enriched gene catalogue provides the most comprehensive picture of the molecular composition of the glomerulus currently available, and GlomNet contributes an integrative systems biology approach to the understanding of glomerular signaling networks that operate during development, function, and disease.


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Identification of a Core Set of 58 Gene Transcripts With Broad and Specific Expression in the Microvasculature
Arterioscler. Thromb. Vasc. Biol., August 1, 2008; 28(8): 1469 - 1476.
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