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Planar Cell Polarity and the Kidney

Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada

Correspondence: Dr. Helen McNeill, Samuel Lunenfeld Research Institute, 600 University Avenue SLRI-Room 884, Toronto, Ontario, Canada M5G 1X5. Phone: 416-586-4800, ext. 8267; Fax: 416-586-8644; E-mail: mcneill{at}mshri.on.ca

Planar cell polarity (PCP) is a form of spatial organization in tissue that was first described in Drosophila melanogaster. PCP plays a critical conserved role in several aspects of mammalian development. Exciting data implicate PCP in normal kidney development and suggest the loss of oriented cell division and convergent extension downstream of defective PCP signaling lead to cystic kidney disease in mouse models. In this review, I first cover the current knowledge of PCP signaling in invertebrate and vertebrate models and then explore how loss of PCP might underlie some forms of cystic kidney disease.

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673