Journal of the American Society of Nephrology
2008 JASN IMPACT FACTOR 7.505 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on November 16, 2009
J Am Soc Nephrol 20: 2604-2615, 2009
© 2009 American Society of Nephrology
doi: 10.1681/ASN.2009010122
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
ASN.2009010122v1
ASN.2009010122v2
20/12/2604    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Smeets, B.
Right arrow Articles by Moeller, M. J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smeets, B.
Right arrow Articles by Moeller, M. J.
Related Collections
Right arrowRelated Article

BASIC RESEARCH

Tracing the Origin of Glomerular Extracapillary Lesions from Parietal Epithelial Cells

Bart Smeets*,{dagger}, Sandra Uhlig*, Astrid Fuss*, Fieke Mooren{ddagger}, Jack F.M. Wetzels§, Jürgen Floege*,{dagger} and Marcus J. Moeller*,{dagger}

*Division of Nephrology and Immunology and
{dagger}Interdisciplinary Centre for Clinical Research "BIOMAT", University Hospital of the Aachen University of Technology, Aachen, Germany; and
Departments of {ddagger}Pathology and
§Nephrology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

Correspondence: Dr. Marcus J. Moeller, Department of Nephrology and Immunology, University Hospital of the Aachen University of Technology, Pauwelsstrasse 30, 52074 Aachen, Germany. Phone: ++49-241-8089530; Fax: ++49-241-8082446; E-mail: mmoeller{at}ukaachen.de

Received for publication January 30, 2009. Accepted for publication September 22, 2009.

Cellular lesions form in Bowman's space in both crescentic glomerulonephritis and collapsing glomerulopathy. The pathomechanism and origin of the proliferating cells in these lesions are unknown. In this study, we examined proliferating cells by lineage tracing of either podocytes or parietal epithelial cells (PECs) in the nephrotoxic nephritis model of inflammatory crescentic glomerulonephritis. In addition, we traced the fate of genetically labeled PECs in the Thy-1.1 transgenic mouse model of collapsing glomerulopathy. In both models, cellular bridges composed of PECs were observed between Bowman's capsule and the glomerular tuft. Genetically labeled PECs also populated larger, more advanced cellular lesions. In these lesions, we detected de novo expression of CD44 in activated PECs. In contrast, we rarely identified genetically labeled podocytes within the cellular lesions of crescentic glomerulonephritis. In conclusion, PECs constitute the majority of cells that compose early extracapillary proliferative lesions in both crescentic glomerulonephritis and collapsing glomerulopathy, suggesting similar pathomechanisms in both diseases.


Related Article

This Month's Highlights
J. Am. Soc. Nephrol. 2009 20: A10. [Full Text] [PDF]





HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673