Journal of the American Society of Nephrology
2008 JASN IMPACT FACTOR 7.505 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on April 15, 2009
J Am Soc Nephrol 20: 1246-1253, 2009
© 2009 American Society of Nephrology
doi: 10.1681/ASN.2008070754
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
ASN.2008070754v1
20/6/1246    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Asplin, J. R.
Right arrow Articles by Bushinsky, D. A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Asplin, J. R.
Right arrow Articles by Bushinsky, D. A.

BASIC RESEARCH

Thiosulfate Reduces Calcium Phosphate Nephrolithiasis

John R. Asplin*, Susan E. Donahue*, Christina Lindeman*, Anne Michalenka{dagger}, Kelly Laplante Strutz{dagger} and David A. Bushinsky{dagger}

* Litholink Corporation, Chicago, Illinois; and {dagger} Nephrology Division, Department of Medicine, University of Rochester School of Medicine, Rochester, New York

Correspondence: Dr. John R. Asplin, Litholink Corp., 2250 W. Campbell Park Drive, Chicago, IL 60612. Phone: 312-243-0600; Fax: 312-243-3297; E-mail: jasplin{at}litholink.com

Received for publication July 18, 2008. Accepted for publication December 26, 2008.

An uncontrolled trial reported that sodium thiosulfate reduces formation of calcium kidney stones in humans, but this has not been established in a controlled human study or animal model. Using the genetic hypercalciuric rat, an animal model of calcium phosphate stone formation, we studied the effect of sodium thiosulfate on urine chemistries and stone formation. We fed genetic hypercalciuric rats normal food with or without sodium thiosulfate for 18 wk and measured urine chemistries, supersaturation, and the upper limit of metastability of urine. Eleven of 12 untreated rats formed stones compared with only three of 12 thiosulfate-treated rats (P < 0.002). Urine calcium and phosphorus were higher and urine citrate and volume were lower in the thiosulfate-treated rats, changes that would increase calcium phosphate supersaturation. Thiosulfate treatment lowered urine pH, which would lower calcium phosphate supersaturation. Overall, there were no statistically significant differences in calcium phosphate supersaturation or upper limit of metastability between thiosulfate-treated and control rats. In vitro, thiosulfate only minimally affected ionized calcium, suggesting a mechanism of action other than calcium chelation. In summary, sodium thiosulfate reduces calcium phosphate stone formation in the genetic hypercalciuric rat. Controlled trials testing the efficacy and safety of sodium thiosulfate for recurrent kidney stones in humans are needed.






HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673