Journal of the American Society of Nephrology
2008 JASN IMPACT FACTOR 7.505 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on July 23, 2009
J Am Soc Nephrol 20: 1901-1905, 2009
© 2009 American Society of Nephrology
doi: 10.1681/ASN.2008121269
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
ASN.2008121269v1
ASN.2008121269v2
20/9/1901    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Bos, E. M.
Right arrow Articles by van Goor, H.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bos, E. M.
Right arrow Articles by van Goor, H.

BRIEF COMMUNICATIONS

Hydrogen Sulfide-Induced Hypometabolism Prevents Renal Ischemia/Reperfusion Injury

Eelke M. Bos*,{dagger}, Henri G.D. Leuvenink{dagger}, Pauline M. Snijder*,{dagger}, Niels J. Kloosterhuis*, Jan-Luuk Hillebrands*, Jaklien C. Leemans{ddagger}, Sandrine Florquin{ddagger} and Harry van Goor*

*Department of Pathology and Medical Biology and
{dagger}Department of Surgery, University Medical Center Groningen, University of Groningen, The Netherlands; and
{ddagger}Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands

Correspondence: Eelke M. Bos, Department of Pathology and Medical Biology, University Medical Center Groningen, PO Box 30.001, Hanzeplein 1, 9700RB Groningen, The Netherlands. Phone: +31-50-3614179; Fax: +31-50-3632796; E-mail: e.m.bos{at}path.umcg.nl

Received for publication December 16, 2008. Accepted for publication May 20, 2009.

Hydrogen sulfide (H2S) can induce a hypometabolic, hibernation-like state in mammals when given in subtoxic concentrations. Pharmacologically reducing the demand for oxygen is a promising strategy to minimize unavoidable hypoxia-induced injury such as ischemia/reperfusion injury during renal transplantation. Here we show that H2S reduces metabolism in vivo, ex vivo, and in vitro. Furthermore, we demonstrate the beneficial effects of H2S-induced hypometabolism in a model of bilateral renal ischemia/reperfusion injury using three different treatment strategies. The results demonstrate striking protective effects on survival, renal function, apoptosis, and inflammation. A hypometabolic state induced by H2S might have therapeutic potential to protect kidneys that suffer from hypoxia.






HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673