Journal of the American Society of Nephrology
2008 JASN IMPACT FACTOR 7.505 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on August 6, 2009
J Am Soc Nephrol 20: 1941-1952, 2009
© 2009 American Society of Nephrology
doi: 10.1681/ASN.2008090976
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
ASN.2008090976v1
20/9/1941    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Sarav, M.
Right arrow Articles by Quigg, R. J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sarav, M.
Right arrow Articles by Quigg, R. J.

BASIC RESEARCH

Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG

Menaka Sarav, Ying Wang, Bradley K. Hack, Anthony Chang, Mark Jensen, Lihua Bao and Richard J. Quigg

Section of Nephrology, Department of Medicine, The University of Chicago, Chicago, Illinois

Correspondence: Dr. Richard Quigg, Section of Nephrology, The University of Chicago, 5841 South Maryland Avenue, MC5100, AMB-S523, Chicago, IL 60637. Phone: +1-773-702-0757; Fax: +1-773-702-4816; E-mail: rquigg{at}uchicago.edu

Received for publication September 15, 2008. Accepted for publication April 23, 2009.

The widely distributed neonatal Fc receptor (FcRn) contributes to maintaining serum levels of albumin and IgG in adults. In the kidney, FcRn is expressed on the podocytes and the brush border of the proximal tubular epithelium. Here, we evaluated the role of renal FcRn in albumin and IgG metabolism. Compared with wild-type controls, FcRn–/– mice had a lower t1/2 for albumin (28.7 versus 39.9 h) and IgG (29.5 versus 66.1 h). Renal loss of albumin could account for the former, suggested by the progressive development of hypoalbuminemia in wild-type mice transplanted with FcRn-deficient kidneys. Furthermore, serum albumin levels returned to normal in FcRn–/– recipients of wild-type kidneys after removing the native FcRn-deficient kidneys. In contrast, renal loss could not account for the enhanced elimination of IgG in FcRn–/– mice. These mice had minimal urinary excretion of native and labeled IgG, which increased to wild-type levels in FcRn–/– recipients of a single FcRn-sufficient kidney (t1/2 of IgG was 21.7 h). Taken together, these data suggest that renal FcRn reclaims albumin, thereby maintaining the serum concentration of albumin, but facilitates the loss of IgG from plasma protein pools.






HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673