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Cytomegalovirus-Induced T Cells Associate with Reduced Cancer Risk after Kidney Transplantation

Lionel Couzi^*,,, Yann Levaillant^*, Abdellah Jamai^*, Vincent Pitard^,, Regis Lassalle, Karin Martin^*,, Isabelle Garrigue^*,, Omar Hawchar^,, François Siberchicot^*,, Nicholas Moore^*,, Jean-François Moreau^*,,, Julie Dechanet-Merville^, and Pierre Merville^*,,

*Centre Hospitalier Universitaire Bordeaux, Hôpital Pellegrin, Bordeaux, France;
Centre National de la Recherche Scientifique Unité Mixte de Recherche 5164, Bordeaux, France; and
Université Bordeaux, Bordeaux, France

Correspondence: Dr. Julie Dechanet-Merville, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5164, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, France. Phone: 33-5-57-57-14-71; Fax: 33-5-57-57-14-72; E-mail: julie.dechanet{at}u-bordeaux2.fr

Received for publication October 14, 2008. Accepted for publication July 19, 2009.

An increase in the number of blood T cells follows cytomegalovirus (CMV) infection in kidney transplant recipients. These cells react against CMV-infected cells and tumor epithelial cells in vitro. We hypothesized that these CMV-induced T cells play a protective role against cancer in kidney transplant recipients. We performed a longitudinal case-control study involving 18 recipients who developed cancer between 2 and 6 yr after transplantation and 45 recipients who did not. The median percentage of T cells among total lymphocytes in patients with malignancies was significantly lower compared with that in control patients at 6, 12, and 18 mo before the diagnosis of cancer. Patients with a T cell percentage of more than 4% were protected from cancer. An increase of the V2^neg T cell subset significantly associated with lower incidence of cancer only in recipients who experienced pre- or postgraft CMV infection. Finally, a retrospective follow-up of 131 recipients for 8 yr revealed that CMV-naive recipients had an approximately 5-fold higher risk of cancer compared with CMV-exposed patients. In summary, these results suggest a protective role of CMV exposure against cancer in kidney transplant recipients.

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Protection from Cancer in Kidney Transplant Patients by T Cells: Role of CMV Infection?

Cecilia Söderberg-Nauclér
J. Am. Soc. Nephrol. 2010 21: 11-13. [Full Text] [PDF]

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				C. Soderberg-Naucler Protection from Cancer in Kidney Transplant Patients by {gamma}{delta} T Cells: Role of CMV Infection? J. Am. Soc. Nephrol., January 1, 2010; 21(1): 11 - 13. [Full Text] [PDF]

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673