Journal of the American Society of Nephrology, Vol 3, 28-34, Copyright © 1992 by American Society of Nephrology

REVIEWS

Gene mapping in experimental hypertension

TW Kurtz and EM St. Lezin

In the rat, the results of genetic linkage studies by "candidate" gene or "positional mapping" approaches have suggested that DNA sequences that regulate blood pressure may be located in the vicinity of the kallikrein gene family on chromosome 1, the gene for angiotensin- converting enzyme on chromosome 10, the renin gene on chromosome 13, and the major histocompatibility complex on chromosome 20. Some studies have also suggested that blood pressure regulatory genes may be located on the sex chromosomes. Pending the results of confirmatory studies, these experiments should be interpreted with caution. However, with confirmation of these studies, it should be possible to create a variety of new animal models that will provide excellent opportunities for investigating the molecular, biochemical, and physiologic determinants of high blood pressure. In addition, in genetic studies in humans with essential hypertension, it may be worthwhile to target chromosome regions that are homologous to those implicated in linkage studies of hypertension in rodents. By narrowing the focus on selected areas of the genome, experimental linkage studies in the rat may also be used to guide the detailed molecular approaches ultimately required to identify the specific DNA sequence alterations that give rise to increased blood pressure.

This article has been cited by other articles:

				K. E. Moss and D. A. Isenberg Comparison of renal disease severity and outcome in patients with primary antiphospholipid syndrome, antiphospholipid syndrome secondary to systemic lupus erythematosus (SLE) and SLE alone Rheumatology, August 1, 2001; 40(8): 863 - 867. [Abstract] [Full Text] [PDF]

				M.H. Griffiths, L. Papadaki, and G.H. Neild The renal pathology of primary antiphospholipid syndrome: a distinctive form of endothelial injury QJM, July 1, 2000; 93(7): 457 - 467. [Abstract] [Full Text] [PDF]

				S.-A. Stephenson, K. Verity, L. K. Ashworth, and J. A. Clements Localization of a New Prostate-specific Antigen-related Serine Protease Gene, KLK4, Is Evidence for an Expanded Human Kallikrein Gene Family Cluster on Chromosome 19q13.3-13.4 J. Biol. Chem., August 13, 1999; 274(33): 23210 - 23214. [Abstract] [Full Text] [PDF]

				D. NOCHY, E. DAUGAS, D. DROZ, H. BEAUFILS, J.-P. GRÜNFELD, J.-C. PIETTE, J. BARIETY, and G. HILL The Intrarenal Vascular Lesions Associated with Primary Antiphospholipid Syndrome J. Am. Soc. Nephrol., March 1, 1999; 10(3): 507 - 518. [Abstract] [Full Text]

				H. M. Kubisch, S. Mathialagan, and E. P. Gomez-Sanchez Modulation of Blood Pressure in the Dahl SS/jr Rat by Embryo Transfer Hypertension, January 1, 1998; 31(1): 540 - 545. [Abstract] [Full Text] [PDF]

				G. Sirokman, D. E. Humphries, and O. H. L. Bing Endogenous Retroviral Transcripts in Myocytes From Spontaneously Hypertensive Rats Hypertension, July 1, 1997; 30(1): 88 - 93. [Abstract] [Full Text]

				J. H. Krege, J. B. Hodgin, J. R. Hagaman, and O. Smithies A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice Hypertension, May 1, 1995; 25(5): 1111 - 1115. [Abstract] [Full Text]

				T. J. Harvey, J. D. Hooper, S. A. Myers, S.-A. Stephenson, L. K. Ashworth, and J. A. Clements Tissue-specific Expression Patterns and Fine Mapping of the Human Kallikrein (KLK) Locus on Proximal 19q13.4 J. Biol. Chem., November 22, 2000; 275(48): 37397 - 37406. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673