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Journal of the American Society of Nephrology, Vol 3, 229-235, Copyright © 1992 by American Society of Nephrology

REGULAR ARTICLES

Large glomerular size in Pima Indians: lack of change with diabetic nephropathy

K Schmidt, C Pesce, Q Liu, RG Nelson, PH Bennett, H Karnitschnig, LJ Striker and GE Striker
Renal Cell Biology Section, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892.

The mean glomerular volume, glomerular fraction of cortical volume, and percentage of obsolescent glomeruli were calculated in kidney specimens from autopsies on 34 Pima Indians, of whom 15 had non-insulin dependent diabetes mellitus and kidney disease of diabetes mellitus. These values were compared with those of black, white, and non-Pima native American individuals without diabetes mellitus. Glomerular volume in the Pima Indians was similar in the diabetic and nondiabetic subjects and significantly greater than in the white subjects. Black and non-Pima native American individuals had glomerular volumes intermediate between white individuals and Pima Indians. The mean glomerular volume was not affected by the number of obsolescent glomeruli in diabetic Pima Indians. The glomerular volume fraction was greater in the Pimas than in the other groups. These data showed that glomerular volume in the Pima Indians was significantly greater than that in white subjects. There was no difference between diabetic and nondiabetics Pimas, and glomerular size was not correlated with the presence or degree of glomerulosclerosis in this population.


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