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Journal of the American Society of Nephrology, Vol 3, S50-S55, Copyright © 1992 by American Society of Nephrology

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Abnormalities in Na+/H+ antiporter activity in diabetic nephropathy

LL Ng and JE Davies
Department of Pharmacology, Leicester Royal Infirmary, United Kingdom.

In hypertensive humans and the spontaneously hypertensive rat, increased cellular Na+/H+ antiport activity has been demonstrated in leukocytes, platelets, skeletal muscle, and vascular smooth muscle cells. This membrane abnormality may be associated with medial thickening of resistance vessels. A similar membrane transport abnormality has also been demonstrated in leukocytes and fibroblasts from type 1 diabetic patients with nephropathy. This membrane transport marker of hypertension may indicate a predisposition to essential hypertension in such patients and may lead to diabetic nephropathy, possibly from mesangial expansion.




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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673