Journal of the American Society of Nephrology, Vol 3, 1201-1211, Copyright © 1992 by American Society of Nephrology

EDITORIALS

Intercellular adhesion molecules and vascular cell adhesion molecule-1 and the kidney

RP Wuthrich
Division of Nephrology and Nephrology Research, Department of Medicine, University of Alabama, Birmingham.

Adhesion molecules such as intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 are expressed in the kidney and are regulated by proinflammatory cytokines. These adhesion molecules play an important role in the binding and activation process of leukocytes and are of importance in inflammatory kidney diseases. This review article describes current knowledge regarding the structure, expression, and functional role of adhesion molecules and their significance in immune-mediated renal diseases.

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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673