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Journal of the American Society of Nephrology, Vol 3, 1312-1320, Copyright © 1992 by American Society of Nephrology

REGULAR ARTICLES

Amelioration of ischemic acute renal failure by dietary fish oil administration in conscious dogs

HH Neumayer, M Heinrich, M Schmissas, H Haller, K Wagner and FC Luft
Department of Internal Medicine-Nephrology, Free University of Berlin, Germany.

The hypothesis that dietary fish oil would protect dogs from ischemic acute renal failure was tested. Fish oil (eicosapentaenoic acid, 55 mg/kg per day, and docosahexaenoic acid, 40 mg/kg per day was given to eight instrumented, female, beagle dogs for 6 wk, while seven control dogs received vehicle. After 3 wk, unilateral nephrectomy was performed and a pneumatic cuff with flow probe was placed around the remaining renal artery of each dog. Three weeks thereafter, the cuff was inflated for 120 min. Renal function, RBF, and prostanoid excretion were measured 24 and 72 h after ischemia. In dogs receiving fish oil, blood pressure, GFR, RBF, renal vascular resistance (RVR), cholesterol, triglycerides, and prostanoid excretion were measured weekly for 6 wk. Further, cytosolic calcium was measured before and five times after fish oil. Blood pressure decreased, serum cholesterol and triglycerides decreased, and the cytosolic calcium within platelets decreased. The urinary excretion (expressed as picograms per milligram of creatinine) of the thromboxane (TX) metabolite TXB2 and the excretion of prostaglandin (PG)E2, as well as the excretion of the PGI2 metabolite 6- keto PGF1 alpha were decreased. GFR, RBF (Cl inulin and Cl para- aminohippuric acid), and RVR were not influenced by fish oil. Unilateral nephrectomy decreased GFR and RBF and increased RVR as expected, whereas it further decreased prostanoid excretion. Acute renal ischemia caused a significant, reversible decrease in GFR and urine volume in vehicle-treated animals, whereas no significant effect on renal function or urine volume was observed in animals pretreated with fish oil.(ABSTRACT TRUNCATED AT 250 WORDS)


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M. L. Kielar, D. R. Jeyarajah, X. J. Zhou, and C. Y. Lu
Docosahexaenoic Acid Ameliorates Murine Ischemic Acute Renal Failure and Prevents Increases in mRNA Abundance for both TNF-{alpha} and Inducible Nitric Oxide Synthase
J. Am. Soc. Nephrol., February 1, 2003; 14(2): 389 - 396.
[Abstract] [Full Text] [PDF]


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