Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DiBona, G. F.
Right arrow Articles by Jones, S. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DiBona, G. F.
Right arrow Articles by Jones, S. Y.

Journal of the American Society of Nephrology, Vol 4, 1792-1797, Copyright © 1994 by American Society of Nephrology

REGULAR ARTICLES

Role of endogenous peripheral opioid mechanisms in renal function

GF DiBona and SY Jones
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 522420.

The role of endogenous peripheral opioid mechanisms in renal function was evaluated in normotensive and hypertensive rats. Intravenous naloxone methylbromide, a quaternary opioid antagonist with limited ability to cross the blood-brain barrier, was used to inhibit endogenous peripheral opioid mechanisms. In normotensive rats, the opioid antagonist impaired the normal renal adaptive response to dietary sodium restriction. In spontaneously hypertensive rats, the opioid antagonist did not affect the renal functional responses to acute environmental stress. These data indicate that, depending on the nature of the intervention, a role for endogenous peripheral opioid mechanisms in the renal function responses may be identified.




HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673