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Journal of the American Society of Nephrology, Vol 4, 2040-2049, Copyright © 1994 by American Society of Nephrology

REGULAR ARTICLES

Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse

G Kawa, S Nagao, A Yamamoto, K Omori, Y Komatz, H Takahashi and Y Tashiro
Department of Urology, Kansai Medical University, Osaka, Japan.

Recently, it has been reported that Na,K-ATPase in the renal epithelia of human autosomal dominant polycystic kidney disease and cpk mouse, a murine model of autosomal recessive polycystic kidney disease, mislocates to apical plasma membrane and that mislocated Na,K-ATPase causes the cyst formation. Whether the DBA/2FG-pcy mice, which are presumably a suitable model for autosomal dominant polycystic kidney disease, also exhibit the reversal polarity of Na,K-ATPase localization was examined. Kidneys of newborn DBA/2FG-pcy mice, and those at early and late stages of cyst development were examined by immunohistochemical techniques. At any stage, abnormal distribution of Na,K-ATPase on the apical membranes of tubular epithelial cells could not be detected. It is suggested that cysts can be formed without reversed polarity of Na,K-ATPase distribution in pcy mice.


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