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Journal of the American Society of Nephrology, Vol 4, 137-141, Copyright © 1993 by American Society of Nephrology

REGULAR ARTICLES

White clot syndrome associated with renal failure

DL Somers, C Sotolongo and JA Bertolatus
Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City 52242.

In a minority of patients, heparin administration is associated with thrombocytopenia and this thrombocytopenia may be associated with thromboembolic events. Heparin-associated thromboembolism is described as heparin-associated thrombocytopenia and thrombosis or white clot syndrome. White clot syndrome is caused by antibodies to a heparin- platelet membrane complex. The diagnosis carries a high mortality and morbidity from limb thromboembolism. Treatment includes discontinuation of heparin, use of alternate anticoagulants, and aggressive treatment of thromboses. A case in which acute renal failure occurred in the setting of heparin treatment and thrombocytopenia is described, and evidence that renal failure was a result of white clot syndrome is provided.


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[Abstract] [Full Text] [PDF]


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