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Journal of the American Society of Nephrology, Vol 4, 235-242, Copyright © 1993 by American Society of Nephrology

REGULAR ARTICLES

Detection of platelet-activating factor in plasma of patients with streptococcal nephritis

S Mezzano, M Kunick, F Olavarria, L Ardiles, G Montrucchio, L Silvestro, L Biancone and G Camussi
Division of Nephrology, School of Medicine, Universidad Austral, Valdivia, Chile.

The purpose of this study was to evaluate whether platelet-activating factor (PAF) is released in the plasma of patients with acute poststreptococcal glomerulonephritis, because previous studies have shown an involvement of platelets in the active phase of this disease. The results of this study indicate that PAF bioactive material is released in significant amounts in the plasma of 49 out of 50 patients with acute poststreptococcal glomerulonephritis. The observed release of PAF was not a direct consequence of the bacterial infection, because it was minimal or absent in patients with streptococcal infection without glomerular involvement. PAF bioactive material extracted and purified from the plasma of patients was shown to be chemically and biologically identical to the synthetic C-16 PAF (1-O-hexadecyl-2- acetyl-sn-glyceryl 3-phosphorylcholine).




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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673