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Journal of the American Society of Nephrology, Vol 4, 969-975, Copyright © 1993 by American Society of Nephrology

EDITORIALS

The mammalian Na+/H+ exchanger gene family--initial structure/function studies

M Tse, S Levine, C Yun, S Brant, J Pouyssegur and M Donowitz

A gene family of mammalian Na+/H+ exchangers has been identified. Three isoforms have been cloned, sequenced, and stably expressed, and structure/function studies have been begun. Several of the isoforms are found in the epithelia, and one of them is epithelial specific.


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