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Journal of the American Society of Nephrology, Vol 4, 1205-1213, Copyright © 1993 by American Society of Nephrology


REGULAR ARTICLES

Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error

JT Daugirdas
Department of Medicine and Research, Westside V.A. Medical Center, Chicago, IL 60612.

The original formula proposed to estimate variable-volume single-pool (VVSP) Kt/V was Kt/V = -In(R - 0.008 * t - f * UF/W), where in the Kt/V range of 0.7 to 1.3, f = 1.0 (* denotes multiplication). This formula tends to overestimate Kt/V as the Kt/V increases above 1.3. Because higher Kt/V values are now commonly delivered, the validity of both the urea generation term (0.008 * f) and correction for UF/W were explored by solving VVSP equations for simulated hemodialysis situations, with Kt/V ranging from 0.6 to 2.6. The analysis led to the development of a second-generation formula, namely: Kt/V = -In(R - 0.008 * t) + (4-3.5 * R) * UF/W. The first and second generation formulas were then used to estimate the modeled VVSP Kt/V in 500 modeling sessions in which the Kt/V ranged widely from 0.7 to 2.1. An analysis of error showed that this second-generation formula eliminated the overestimation of Kt/V in the high ranges found with the first-generation formula. Also, total error (absolute value percent error + 2 SD) was reduced with the second- generation formula. These results led to the proposal of a new formula that can be used for a very wide range of delivered Kt/V.


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Nephrol. Dial. Transplant., May 1, 2001; 16(5): 994 - 998.
[Abstract] [Full Text] [PDF]


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M. Giordano, D. Manzella, G. Paolisso, A. Caliendo, M. Varricchio, and C. Giordano
Differences in heart rate variability parameters during the post-dialytic period in type II diabetic and non-diabetic ESRD patients
Nephrol. Dial. Transplant., March 1, 2001; 16(3): 566 - 573.
[Abstract] [Full Text] [PDF]