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Journal of the American Society of Nephrology, Vol 5, 1740-1744, Copyright © 1995 by American Society of Nephrology

REVIEWS

Rapidly progressive glomerulonephritis after immunotherapy for cancer

MG Parker, MB Atkins, AA Ucci and AS Levey
Division of Nephrology, New England Medical Center, Boston, MA, USA.

Cytokines have been used in experimental and standard protocols for immune enhancement for cancer. The combination of interleukin-2 and interferon-alpha 2 beta has been used in experimental protocols for metastatic renal cell carcinoma. A man who developed rapidly progressive renal failure after receiving this combination therapy is reported. A renal biopsy revealed a pauci-immune crescentic glomerulonephritis. Antineutrophil cytoplasmic antibodies and antiglomerular basement membrane antibodies were absent. The spectrum of renal disease and potentially related extrarenal manifestations associated with interleukin-2 and inteferon-alpha are reviewed. A pathogenesis of altered cell-mediated immunity, consistent with abnormalities in extrarenal organs after immune enhancement, is proposed.


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IFN-{alpha} induces barrier destabilization and apoptosis in renal proximal tubular epithelium
Am J Physiol Cell Physiol, January 1, 2008; 294(1): C153 - C160.
[Abstract] [Full Text] [PDF]


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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673