Journal of the American Society of Nephrology, Vol 5, 1806-1810, Copyright © 1995 by American Society of Nephrology

REGULAR ARTICLES

Familial risk, age at onset, and cause of end-stage renal disease in white Americans

BJ Spray, NG Atassi, AB Tuttle and BI Freedman
Department of Public Health Sciences, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1053, USA.

A strong familial clustering of ESRD has been reported among African Americans, suggesting that factors predisposing to renal failure, whether genetic, environmental, or both, may disproportionately affect certain families. A case-control study was undertaken to determine if a familial risk of ESRD was present among white Americans, if this risk differed among causes of ESRD, and if variability in age at onset was attributed to familial factors. Data were obtained from 103 white American patients (cases) with ESRD receiving dialysis treatments at the Bowman Gray School of Medicine's affiliated dialysis facility in Winston-Salem, NC. One hundred three age-, sex- and race-matched non- ESRD controls were consecutively selected from the Wake Forest University Physicians internal medicine clinic. Odds ratios (OR) and associated 95% confidence intervals (CI) were calculated to signify the prevalence of a relative with ESRD among cases versus controls. The presence of either a first- or second-degree relative increased a white American's risk for developing ESRD nearly threefold (OR = 2.7, 95% CI 1.1 to 7.2; P = 0.038), whereas the presence of either a first-, second- or third-degree relative with ESRD increased the risk nearly fourfold (OR = 3.5, 95% CI 1.5 to 8.4; P = 0.004). Cases with chronic glomerulonephritis and Type II diabetic nephropathy as the cause of ESRD had relatives with ESRD more often than cases with Type I diabetic nephropathy, interstitial nephritis, or renal artery stenosis. The average correlation (f) of ages at onset of ESRD among individuals in a single family (cases and their relatives) was 55%.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				M. R. Garrett, W. T. Gunning, T. Radecki, and A. Richard Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21 Physiol Genomics, August 20, 2007; 30(3): 322 - 334. [Abstract] [Full Text] [PDF]

				J. Gumprecht, M. J. Zychma, D. Karasek, and W. Grzeszczak ACE gene I/D polymorphism and the presence of renal failure or hypertension in autosomal dominant polycystic kidney disease (ADPKD) Nephrol. Dial. Transplant., May 1, 2007; 22(5): 1483 - 1483. [Full Text] [PDF]

				R. L. Hanson, D. W. Craig, M. P. Millis, K. A. Yeatts, S. Kobes, J. V. Pearson, A. M. Lee, W. C. Knowler, R. G. Nelson, and J. K. Wolford Identification of PVT1 as a Candidate Gene for End-Stage Renal Disease in Type 2 Diabetes Using a Pooling-Based Genome-Wide Single Nucleotide Polymorphism Association Study Diabetes, April 1, 2007; 56(4): 975 - 983. [Abstract] [Full Text] [PDF]

				B. I. Freedman Susceptibility Genes for Hypertension and Renal Failure J. Am. Soc. Nephrol., July 1, 2003; 14(90002): S192 - 194. [Abstract] [Full Text] [PDF]

				M. R. Garrett, H. Dene, and J. P. Rapp Time-Course Genetic Analysis of Albuminuria in Dahl Salt-Sensitive Rats on Low-Salt Diet J. Am. Soc. Nephrol., May 1, 2003; 14(5): 1175 - 1187. [Abstract] [Full Text] [PDF]

				J. Gumprecht, M. J. Zychma, W. Grzeszczak, and E. Zukowska-Szczechowska Human SA gene Pst1 polymorphism and chronic renal failure: Results of the family-based study Nephrol. Dial. Transplant., February 1, 2001; 16(2): 387 - 390. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673