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Journal of the American Society of Nephrology, Vol 5, 2020-2023, Copyright © 1995 by American Society of Nephrology

REGULAR ARTICLES

Exercise-induced acute renal failure associated with ibuprofen, hydrochlorothiazide, and triamterene

LR Sanders
Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, USA.

Nonsteroidal anti-inflammatory drugs predispose to acute renal failure in conditions associated with decreased RBF. Such conditions include advanced age, hypertension, chronic renal insufficiency, diuretic use, and any condition decreasing effective circulating volume. Strenuous exercise also causes marked reductions in RBF. The patient discussed developed severe acute renal failure after strenuous exercise and therapeutic doses of ibuprofen and hydrochlorothiazide-triamterene. Urinalysis showed a nephritic sediment with red blood cell casts. Renal biopsy showed acute tubular necrosis and arteriolar nephrosclerosis. Although exercise-associated acute renal failure is uncommon, susceptible patients with exercise-induced renal ischemia and prostaglandin inhibition may develop this complication.


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 Nephrol Dial TransplantHome page
T. Ohta, T. Sakano, T. Igarashi, N. Itami, and T. Ogawa
Exercise-induced acute renal failure associated with renal hypouricaemia: results of a questionnaire-based survey in Japan
Nephrol. Dial. Transplant., June 1, 2004; 19(6): 1447 - 1453.
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Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673