Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tan, A. U.
Right arrow Articles by Levine, B. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tan, A. U., Jr
Right arrow Articles by Levine, B. S.

Journal of the American Society of Nephrology, Vol 5, 1653-1658, Copyright © 1995 by American Society of Nephrology

REGULAR ARTICLES

Renal amyloidosis in a drug abuser

AU Tan Jr, AH Cohen and BS Levine
Department of Medicine, VAMC West Los Angeles, CA 90073, USA.

Drug abusers, particularly those who inject drugs s.c. ("skin popping"), may develop amyloidosis. Chronic infections are thought to play a pathogenetic role in this setting. A patient is presented who had a history of "skin popping" cocaine and heroin and developed nephrotic syndrome, with an elevated serum creatinine and a creatinine clearance of 61 mL/min. Renal biopsy demonstrated amyloidosis. Treatment with colchicine was initiated, and proteinuria decreased to near normal levels after 12 months. Concomitant with the decrease in proteinuria, creatinine clearance improved, although a repeat renal biopsy failed to show any significant improvement in amyloid burden. These observations suggest that colchicine may be a useful treatment in reversing the proteinuria of renal amyloidosis associated with drug abuse. Furthermore, clinical improvement may occur before any demonstrable regression in the amyloidosis.


This article has been cited by other articles:


Home page
 QJMHome page
J.O. Connolly, J.D. Gillmore, H.J. Lachmann, A. Davenport, P.N. Hawkins, and R.G. Woolfson
Renal amyloidosis in intravenous drug users
QJM, November 1, 2006; 99(11): 737 - 742.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
J. A. Jaffe and P. L. Kimmel
Chronic Nephropathies of Cocaine and Heroin Abuse: A Critical Review
Clin. J. Am. Soc. Nephrol., July 1, 2006; 1(4): 655 - 667.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
B. Thompson, A. Burns, and A. Davenport
Recreational drug abuse in a dialysis patient
Nephrol. Dial. Transplant., April 1, 2002; 17(4): 675 - 676.
[Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673